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A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2–RNA complex
Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos, Andrew J. MacRae, Zackary Falls, Sumit Rai, William W. Brennessel, Jermaine L. Jenkins, Matthew J. Walter, Timothy A. Graubert, Ram Samudrala, Melissa S. Jurica, Alison J. Frontier, Clara L. Kielkopf
doi: https://doi.org/10.1101/2020.09.28.317727
Rakesh Chatrikhi
1Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
7Present address: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Callen F. Feeney
1Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Mary J. Pulvino
1Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Georgios Alachouzos
2Department of Chemistry, University of Rochester, Rochester, NY, USA
8Present address: Stratingh Institute of Chemistry, Rijksuniversiteit Groningen, Nijenborgh 4, 9747AG, Groningen, Netherlands
Andrew J. MacRae
3Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA, USA
9Present address: Gene Regulation, Stem Cells and Cancer Program, Centre de Regulació Genòmica, PRBB Dr. Aiguader 88 08003 Barcelona, Spain
Zackary Falls
4Department of Medical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
Sumit Rai
5Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA
William W. Brennessel
2Department of Chemistry, University of Rochester, Rochester, NY, USA
Jermaine L. Jenkins
1Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Matthew J. Walter
6Department of Medicine, Washington University, St. Louis, MO, USA
Timothy A. Graubert
5Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA
Ram Samudrala
4Department of Medical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA
Melissa S. Jurica
3Department of Molecular, Cell and Developmental Biology and Center for Molecular Biology of RNA, University of California Santa Cruz, Santa Cruz, CA, USA
Alison J. Frontier
2Department of Chemistry, University of Rochester, Rochester, NY, USA
Clara L. Kielkopf
1Department of Biochemistry and Biophysics and Center for RNA Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Posted October 23, 2020.
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2–RNA complex
Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos, Andrew J. MacRae, Zackary Falls, Sumit Rai, William W. Brennessel, Jermaine L. Jenkins, Matthew J. Walter, Timothy A. Graubert, Ram Samudrala, Melissa S. Jurica, Alison J. Frontier, Clara L. Kielkopf
bioRxiv 2020.09.28.317727; doi: https://doi.org/10.1101/2020.09.28.317727
A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2–RNA complex
Rakesh Chatrikhi, Callen F. Feeney, Mary J. Pulvino, Georgios Alachouzos, Andrew J. MacRae, Zackary Falls, Sumit Rai, William W. Brennessel, Jermaine L. Jenkins, Matthew J. Walter, Timothy A. Graubert, Ram Samudrala, Melissa S. Jurica, Alison J. Frontier, Clara L. Kielkopf
bioRxiv 2020.09.28.317727; doi: https://doi.org/10.1101/2020.09.28.317727
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