Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

George R. Nahass; Yuanzi Sun; Yong Xu; Mark Batchelor; Madeleine Reilly; Iryna Benilova; Niraja Kedia; Kevin Spehar; Frank Sobott; Richard B. Sessions; Byron Caughey; Sheena E. Radford; Parmjit Jat; John Collinge; Jan Bieschke

doi:10.1101/2020.09.29.318220

New Results

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

View ORCID ProfileGeorge R. Nahass, Yuanzi Sun, Yong Xu, View ORCID ProfileMark Batchelor, Madeleine Reilly, Iryna Benilova, Niraja Kedia, View ORCID ProfileKevin Spehar, View ORCID ProfileFrank Sobott, View ORCID ProfileRichard B. Sessions, View ORCID ProfileByron Caughey, View ORCID ProfileSheena E. Radford, View ORCID ProfileParmjit Jat, View ORCID ProfileJohn Collinge, View ORCID ProfileJan Bieschke

doi: https://doi.org/10.1101/2020.09.29.318220

George R. Nahass

1Colorado College, Colorado Springs, CO, USA

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

3Washington University in St. Louis, St Louis, MO, USA

7Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for George R. Nahass

Yuanzi Sun

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yong Xu

4Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mark Batchelor

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mark Batchelor

Madeleine Reilly

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Iryna Benilova

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Niraja Kedia

3Washington University in St. Louis, St Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Kevin Spehar

3Washington University in St. Louis, St Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kevin Spehar

Frank Sobott

4Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT UK

5Biomolecular and Analytical Mass Spectrometry group, University of Antwerp, Antwerp, Belgium

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Frank Sobott

Richard B. Sessions

6Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Richard B. Sessions

Byron Caughey

7Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Byron Caughey

Sheena E. Radford

4Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sheena E. Radford

Parmjit Jat

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Parmjit Jat

John Collinge

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for John Collinge

Jan Bieschke

2University College London Institute of Prion Diseases / MRC Prion Unit, London, UK

3Washington University in St. Louis, St Louis, MO, USA

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Jan Bieschke
For correspondence: j.bieschke@ucl.ac.uk

Abstract
Full Text
Info/History
Metrics
Supplementary material
Preview PDF

Article usage

Article usage: October 2020 to January 2021

	Abstract	Full	Pdf
Oct 2020	496	42	70
Nov 2020	118	6	26
Dec 2020	55	14	33
Jan 2021	15	5	8

View the discussion thread.

PreviousNext

Posted October 01, 2020.

Download PDF

Supplementary Material

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

George R. Nahass, Yuanzi Sun, Yong Xu, Mark Batchelor, Madeleine Reilly, Iryna Benilova, Niraja Kedia, Kevin Spehar, Frank Sobott, Richard B. Sessions, Byron Caughey, Sheena E. Radford, Parmjit Jat, John Collinge, Jan Bieschke

bioRxiv 2020.09.29.318220; doi: https://doi.org/10.1101/2020.09.29.318220

Share This Article:

Citation Tools

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

bioRxiv 2020.09.29.318220; doi: https://doi.org/10.1101/2020.09.29.318220

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Biochemistry

Subject Areas

All Articles

Animal Behavior and Cognition (2409)
Biochemistry (4757)
Bioengineering (3299)
Bioinformatics (14579)
Biophysics (6588)
Cancer Biology (5129)
Cell Biology (7376)
Clinical Trials (138)
Developmental Biology (4315)
Ecology (6822)
Epidemiology (2057)
Evolutionary Biology (9838)
Genetics (7308)
Genomics (9467)
Immunology (4506)
Microbiology (12587)
Molecular Biology (4901)
Neuroscience (28097)
Paleontology (198)
Pathology (799)
Pharmacology and Toxicology (1372)
Physiology (1993)
Plant Biology (4450)
Scientific Communication and Education (966)
Synthetic Biology (1293)
Systems Biology (3892)
Zoology (717)