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SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro
View ORCID ProfileAlan C-Y. Hsu, Guoqiang Wang, Andrew T. Reid, Punnam Chander Veerati, Prabuddha S. Pathinayake, Katie Daly, Jemma R. Mayall, Philip M. Hansbro, Jay C. Horvat, Fang Wang, Peter A. Wark
doi: https://doi.org/10.1101/2020.09.30.317818
Alan C-Y. Hsu
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Guoqiang Wang
3Department of Pathogen Biology, College of Basic Medical Science, Jilin University, Changchun 130021, China
Andrew T. Reid
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Punnam Chander Veerati
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Prabuddha S. Pathinayake
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Katie Daly
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Jemma R. Mayall
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Philip M. Hansbro
4School of Life Sciences, University of Technology Sydney, New South Wales 2007, Australia
5Centenary UTS Centre for Inflammation, Centenary Institute, New South Wales 2050, Australia
Jay C. Horvat
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
Fang Wang
3Department of Pathogen Biology, College of Basic Medical Science, Jilin University, Changchun 130021, China
Peter A. Wark
1Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, New South Wales 2305, Australia
2Viruses, Infection / Immunity, Vaccines and Asthma, Hunter Medical Research Institute, Newcastle, New South Wales 2305, Australia
6Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales 2305, Australia
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Posted October 01, 2020.
SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro
Alan C-Y. Hsu, Guoqiang Wang, Andrew T. Reid, Punnam Chander Veerati, Prabuddha S. Pathinayake, Katie Daly, Jemma R. Mayall, Philip M. Hansbro, Jay C. Horvat, Fang Wang, Peter A. Wark
bioRxiv 2020.09.30.317818; doi: https://doi.org/10.1101/2020.09.30.317818
SARS-CoV-2 Spike protein promotes hyper-inflammatory response that can be ameliorated by Spike-antagonistic peptide and FDA-approved ER stress and MAP kinase inhibitors in vitro
Alan C-Y. Hsu, Guoqiang Wang, Andrew T. Reid, Punnam Chander Veerati, Prabuddha S. Pathinayake, Katie Daly, Jemma R. Mayall, Philip M. Hansbro, Jay C. Horvat, Fang Wang, Peter A. Wark
bioRxiv 2020.09.30.317818; doi: https://doi.org/10.1101/2020.09.30.317818
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