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The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
View ORCID ProfileThomas P. Peacock, View ORCID ProfileDaniel H. Goldhill, View ORCID ProfileJie Zhou, View ORCID ProfileLaury Baillon, View ORCID ProfileRebecca Frise, View ORCID ProfileOlivia C. Swann, View ORCID ProfileRuthiran Kugathasan, View ORCID ProfileRebecca Penn, View ORCID ProfileJonathan C. Brown, View ORCID ProfileRaul Y. Sanchez-David, View ORCID ProfileLuca Braga, View ORCID ProfileMaia Kavanagh Williamson, View ORCID ProfileJack A. Hassard, View ORCID ProfileEcco Staller, View ORCID ProfileBrian Hanley, View ORCID ProfileMichael Osborn, View ORCID ProfileMauro Giacca, View ORCID ProfileAndrew D. Davidson, View ORCID ProfileDavid A. Matthews, View ORCID ProfileWendy S. Barclay
doi: https://doi.org/10.1101/2020.09.30.318311
Thomas P. Peacock
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Daniel H. Goldhill
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Jie Zhou
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Laury Baillon
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Rebecca Frise
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Olivia C. Swann
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Ruthiran Kugathasan
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Rebecca Penn
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Jonathan C. Brown
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Raul Y. Sanchez-David
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Luca Braga
2British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, King’s College London, UK, SE5 9RS
Maia Kavanagh Williamson
3School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, UK, BS8 1TD
Jack A. Hassard
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Ecco Staller
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Brian Hanley
4Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, UK, W6 8RF
Michael Osborn
4Department of Cellular Pathology, Northwest London Pathology, Imperial College London NHS Trust, UK, W6 8RF
Mauro Giacca
2British Hearth Foundation Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, King’s College London, UK, SE5 9RS
Andrew D. Davidson
3School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, UK, BS8 1TD
David A. Matthews
3School of Cellular and Molecular Medicine, Faculty of Life Sciences, University of Bristol, UK, BS8 1TD
Wendy S. Barclay
1Department of Infectious Diseases, Imperial College London, UK, W2 1PG.
Article usage
Posted September 30, 2020.
The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
Thomas P. Peacock, Daniel H. Goldhill, Jie Zhou, Laury Baillon, Rebecca Frise, Olivia C. Swann, Ruthiran Kugathasan, Rebecca Penn, Jonathan C. Brown, Raul Y. Sanchez-David, Luca Braga, Maia Kavanagh Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews, Wendy S. Barclay
bioRxiv 2020.09.30.318311; doi: https://doi.org/10.1101/2020.09.30.318311
The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
Thomas P. Peacock, Daniel H. Goldhill, Jie Zhou, Laury Baillon, Rebecca Frise, Olivia C. Swann, Ruthiran Kugathasan, Rebecca Penn, Jonathan C. Brown, Raul Y. Sanchez-David, Luca Braga, Maia Kavanagh Williamson, Jack A. Hassard, Ecco Staller, Brian Hanley, Michael Osborn, Mauro Giacca, Andrew D. Davidson, David A. Matthews, Wendy S. Barclay
bioRxiv 2020.09.30.318311; doi: https://doi.org/10.1101/2020.09.30.318311
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