New Results
GNS561, a clinical-stage PPT1 inhibitor, has powerful antitumor activity against hepatocellular carcinoma via modulation of lysosomal functions
View ORCID ProfileSonia Brun, View ORCID ProfileEric Raymond, Firas Bassissi, View ORCID ProfileZuzana Macek Jilkova, View ORCID ProfileSoraya Mezouar, Madani Rachid, Marie Novello, Jennifer Tracz, Ahmed Hamaï, View ORCID ProfileGilles Lalmanach, Lise Vanderlynden, Eloïne Bestion, Raphael Legouffe, Jonathan Stauber, Thomas Schubert, Maximilian G. Plach, Jérôme Courcambeck, Cyrille Drouot, Guillaume Jacquemot, Cindy Serdjebi, Gael Roth, View ORCID ProfileJean-Pierre Baudoin, Christelle Ansaldi, View ORCID ProfileThomas Decaens, Philippe Halfon
doi: https://doi.org/10.1101/2020.09.30.320010
Sonia Brun
1Genoscience Pharma, Marseille, France
Eric Raymond
1Genoscience Pharma, Marseille, France
2Medical Oncology, Paris Saint-Joseph Hospital, Paris, France
Firas Bassissi
1Genoscience Pharma, Marseille, France
Zuzana Macek Jilkova
3Institute for Advanced Biosciences, Research Center UGA / Inserm U 1209 / CNRS 5309, La Tronche, France
4University Grenoble Alpes, Faculté de médecine, France
5Clinique Universitaire d’Hépato-gastroentérologie, Pôle Digidune, CHU Grenoble, France
Soraya Mezouar
1Genoscience Pharma, Marseille, France
Madani Rachid
1Genoscience Pharma, Marseille, France
Marie Novello
1Genoscience Pharma, Marseille, France
Jennifer Tracz
1Genoscience Pharma, Marseille, France
Ahmed Hamaï
6Institut Necker-Enfants Malades, Inserm U1151-CNRS UMR 8253, Paris, France
7University Paris Descartes-Sorbonne Paris Cité, Paris, France
Gilles Lalmanach
8INSERM, UMR1100, Centre d’Etude des Pathologies Respiratoires, Equipe “Mécanismes Protéolytiques dans l’Inflammation”, Tours, France
9Tours University, Tours, France
Lise Vanderlynden
8INSERM, UMR1100, Centre d’Etude des Pathologies Respiratoires, Equipe “Mécanismes Protéolytiques dans l’Inflammation”, Tours, France
9Tours University, Tours, France
Eloïne Bestion
1Genoscience Pharma, Marseille, France
10CNRS, IRD, MEPHI, IHU Méditerranée Infection, Aix Marseille University, Marseille, France
Raphael Legouffe
11ImaBiotech, Loos, France
Jonathan Stauber
12ImaBiotech, Billerica, USA
Thomas Schubert
132Bind GmbH, Regensburg, Germany
Maximilian G. Plach
132Bind GmbH, Regensburg, Germany
Jérôme Courcambeck
1Genoscience Pharma, Marseille, France
Cyrille Drouot
1Genoscience Pharma, Marseille, France
Guillaume Jacquemot
1Genoscience Pharma, Marseille, France
Cindy Serdjebi
1Genoscience Pharma, Marseille, France
Gael Roth
3Institute for Advanced Biosciences, Research Center UGA / Inserm U 1209 / CNRS 5309, La Tronche, France
4University Grenoble Alpes, Faculté de médecine, France
5Clinique Universitaire d’Hépato-gastroentérologie, Pôle Digidune, CHU Grenoble, France
Jean-Pierre Baudoin
14Aix Marseille University, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France
Christelle Ansaldi
1Genoscience Pharma, Marseille, France
Thomas Decaens
3Institute for Advanced Biosciences, Research Center UGA / Inserm U 1209 / CNRS 5309, La Tronche, France
4University Grenoble Alpes, Faculté de médecine, France
5Clinique Universitaire d’Hépato-gastroentérologie, Pôle Digidune, CHU Grenoble, France
Philippe Halfon
1Genoscience Pharma, Marseille, France
Posted October 01, 2020.
GNS561, a clinical-stage PPT1 inhibitor, has powerful antitumor activity against hepatocellular carcinoma via modulation of lysosomal functions
Sonia Brun, Eric Raymond, Firas Bassissi, Zuzana Macek Jilkova, Soraya Mezouar, Madani Rachid, Marie Novello, Jennifer Tracz, Ahmed Hamaï, Gilles Lalmanach, Lise Vanderlynden, Eloïne Bestion, Raphael Legouffe, Jonathan Stauber, Thomas Schubert, Maximilian G. Plach, Jérôme Courcambeck, Cyrille Drouot, Guillaume Jacquemot, Cindy Serdjebi, Gael Roth, Jean-Pierre Baudoin, Christelle Ansaldi, Thomas Decaens, Philippe Halfon
bioRxiv 2020.09.30.320010; doi: https://doi.org/10.1101/2020.09.30.320010
GNS561, a clinical-stage PPT1 inhibitor, has powerful antitumor activity against hepatocellular carcinoma via modulation of lysosomal functions
Sonia Brun, Eric Raymond, Firas Bassissi, Zuzana Macek Jilkova, Soraya Mezouar, Madani Rachid, Marie Novello, Jennifer Tracz, Ahmed Hamaï, Gilles Lalmanach, Lise Vanderlynden, Eloïne Bestion, Raphael Legouffe, Jonathan Stauber, Thomas Schubert, Maximilian G. Plach, Jérôme Courcambeck, Cyrille Drouot, Guillaume Jacquemot, Cindy Serdjebi, Gael Roth, Jean-Pierre Baudoin, Christelle Ansaldi, Thomas Decaens, Philippe Halfon
bioRxiv 2020.09.30.320010; doi: https://doi.org/10.1101/2020.09.30.320010
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