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Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures

Marcella Birtele, Yogita Sharma, Petter Storm, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parmar
doi: https://doi.org/10.1101/2020.10.01.322495
Marcella Birtele
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Yogita Sharma
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Petter Storm
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Janko Kajtez
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Jenny Nelander Wahlestedt
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Edoardo Sozzi
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Fredrik Nilsson
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Simon Stott
3Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, UK
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Xiaoling L He
3Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, UK
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Bengt Mattsson
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Daniella Rylander Ottosson
2Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, Sweden
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Roger A Barker
3Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, UK
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Alessandro Fiorenzano
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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Malin Parmar
1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
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  • For correspondence: malin.parmar@med.lu.se
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Article Information

doi 
https://doi.org/10.1101/2020.10.01.322495
History 
  • October 1, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Marcella Birtele1,
  2. Yogita Sharma1,
  3. Petter Storm1,
  4. Janko Kajtez1,
  5. Jenny Nelander Wahlestedt1,
  6. Edoardo Sozzi1,
  7. Fredrik Nilsson1,
  8. Simon Stott3,
  9. Xiaoling L He3,
  10. Bengt Mattsson1,
  11. Daniella Rylander Ottosson2,
  12. Roger A Barker3,
  13. Alessandro Fiorenzano1 and
  14. Malin Parmar1,*
  1. 1Developmental and Regenerative Neurobiology, Wallenberg Neuroscience Center, and Lund Stem Cell Centre, Department of Experimental Medical Science, Lund University, Sweden
  2. 2Regenerative Neurophysiology, Wallenberg Neuroscience Center, Lund Stem Cell Center, Department of Experimental Medical Science, Lund University, Sweden
  3. 3Department of Clinical Neuroscience and WT-MRC Cambridge Stem Cell Institute, University of Cambridge, UK
  1. ↵*Corresponding author; email: malin.parmar{at}med.lu.se
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Posted October 01, 2020.
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Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures
Marcella Birtele, Yogita Sharma, Petter Storm, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parmar
bioRxiv 2020.10.01.322495; doi: https://doi.org/10.1101/2020.10.01.322495
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Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures
Marcella Birtele, Yogita Sharma, Petter Storm, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling L He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A Barker, Alessandro Fiorenzano, Malin Parmar
bioRxiv 2020.10.01.322495; doi: https://doi.org/10.1101/2020.10.01.322495

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