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Otx2 stimulates adult retinal ganglion cell regeneration

Raoul Torero-Ibad, Nicole Quenech’du, Alain Prochiantz, Kenneth L. Moya
doi: https://doi.org/10.1101/2020.10.06.327999
Raoul Torero-Ibad
1Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France
2Univ. Lille, CNRS, UMR 8523 - PhLAM - Physique des Lasers Atomes et Molécules, F-59000 Lille, France
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  • For correspondence: raoul.torero@univ-lille.fr ken.moya@college-de-france.fr
Nicole Quenech’du
1Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France
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Alain Prochiantz
1Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France
3BrainEver, 74 rue du Faubourg Saint Antoine, 75012 Paris and Institute of Neurosciences, 320 Yueyang Rd, Shanghai 200031, China
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Kenneth L. Moya
1Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University, Paris, France
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Abstract

Retinal ganglion cell axons provide the only link between the light sensitive and photon transducing neural retina and visual centers of the brain. Retinal ganglion cell axon degeneration occurs in a number of blinding diseases and the ability to stimulate axon regeneration from surviving ganglion cells could provide the anatomic substrate for restoration of vision. OTX2 is a homeoprotein transcription factor expressed in the retina and previous studies showed that, in response to stress, exogenous OTX2 increases the in vitro and in vivo survival of retinal ganglion cells. The present results show that, in addition to promoting adult retinal ganglion cell survival, OTX2 also stimulates the regeneration of their axons in vitro and in vivo. This dual activity of OTX2 on retinal ganglion cell survival and regeneration is of potential interest for degenerative diseases affecting this cell type.

Competing Interest Statement

A.P and K.L.M. are coinventors for the use of Otx2 in eye disease and cofounders of BrainEver.

Footnotes

  • Conflict of interest statement: A.P and K.L.M. are coinventors for the use of Otx2 in eye disease and cofounders of BrainEver.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 07, 2020.
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Otx2 stimulates adult retinal ganglion cell regeneration
Raoul Torero-Ibad, Nicole Quenech’du, Alain Prochiantz, Kenneth L. Moya
bioRxiv 2020.10.06.327999; doi: https://doi.org/10.1101/2020.10.06.327999
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Otx2 stimulates adult retinal ganglion cell regeneration
Raoul Torero-Ibad, Nicole Quenech’du, Alain Prochiantz, Kenneth L. Moya
bioRxiv 2020.10.06.327999; doi: https://doi.org/10.1101/2020.10.06.327999

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