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Dopamine D1 receptor activation drives plasticity in the songbird auditory pallium

View ORCID ProfileMatheus Macedo-Lima, View ORCID ProfileHannah M. Boyd, View ORCID ProfileLuke Remage-Healey
doi: https://doi.org/10.1101/2020.10.09.330266
Matheus Macedo-Lima
1Neuroscience and Behavior Program, University of Massachusetts Amherst, Amherst MA, USA 01003
2Center for Neuroendocrine Studies, University of Massachusetts Amherst, Amherst MA, USA 01003
3CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, Brazil 70040-020
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  • ORCID record for Matheus Macedo-Lima
Hannah M. Boyd
2Center for Neuroendocrine Studies, University of Massachusetts Amherst, Amherst MA, USA 01003
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Luke Remage-Healey
1Neuroscience and Behavior Program, University of Massachusetts Amherst, Amherst MA, USA 01003
2Center for Neuroendocrine Studies, University of Massachusetts Amherst, Amherst MA, USA 01003
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  • For correspondence: lremageh@umass.edu
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Abstract

Vocal learning species must form and extensively hone associations between sounds and social contingencies. In songbirds, dopamine signaling guides song motor-production, variability, and motivation, but it is unclear how dopamine regulates fundamental auditory associations for learning new sounds. We hypothesized that dopamine regulates learning in the auditory pallium, in part by interacting with local neuroestradiol signaling. Here, we show that zebra finch auditory neurons frequently coexpress D1 receptor (D1R) protein, neuroestradiol-synthase, GABA, and parvalbumin. Auditory classical conditioning increased neuroplasticity gene induction in D1R-positive neurons. In vitro, D1R pharmacological activation reduced the amplitude of GABAergic and glutamatergic currents, and increased the latter’s frequency. In vivo, D1R activation reduced the firing of putative interneurons, increased the firing of putative excitatory neurons, and made both neuronal types unable to adapt to novel stimuli. Together, these data support the hypothesis that dopamine acting via D1Rs modulates learning and memory in the songbird sensory cortex.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted October 09, 2020.
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Dopamine D1 receptor activation drives plasticity in the songbird auditory pallium
Matheus Macedo-Lima, Hannah M. Boyd, Luke Remage-Healey
bioRxiv 2020.10.09.330266; doi: https://doi.org/10.1101/2020.10.09.330266
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Dopamine D1 receptor activation drives plasticity in the songbird auditory pallium
Matheus Macedo-Lima, Hannah M. Boyd, Luke Remage-Healey
bioRxiv 2020.10.09.330266; doi: https://doi.org/10.1101/2020.10.09.330266

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