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Intercellular telomere transfer extends T cell lifespan

Bruno Vaz, Claudia Vuotto, Salvatore Valvo, Clara D’Ambra, Francesco Maria Esposito, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Derek Gilroy, Arne N. Akbar, Michael L. Dustin, Michael Karin, View ORCID ProfileAlessio Lanna
doi: https://doi.org/10.1101/2020.10.09.331918
Bruno Vaz
2Laboratory of NeuroImmuneSenescence, IRCCS Fondazione Santa Lucia, Rome. ITALY
3Sentcell ltd, London, UK.
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Claudia Vuotto
4Experimental Neuroscience, IRCCS Fondazione Santa Lucia, Rome. ITALY
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Salvatore Valvo
5Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. United Kingdom.
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Clara D’Ambra
2Laboratory of NeuroImmuneSenescence, IRCCS Fondazione Santa Lucia, Rome. ITALY
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Francesco Maria Esposito
2Laboratory of NeuroImmuneSenescence, IRCCS Fondazione Santa Lucia, Rome. ITALY
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Valerio Chiurchiù
6Institute of Translational Pharmacology, National Research Council, Rome. Italy.
7Laboratory of resolution of NeuroInflammation, IRCCS Santa Lucia Foundation, Rome, Italy.
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Oliver Devine
8Division of Infection and Immunity, University College London, London, UK.
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Massimo Sanchez
9ISS, Core facilities, Rome. Italy.
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Giovanna Borsellino
10NeuroImmunology Unit, IRCCS Fondazione Santa Lucia, Rome. ITALY
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Derek Gilroy
11Division of Medicine, University College London, London, London, UK.
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Arne N. Akbar
8Division of Infection and Immunity, University College London, London, UK.
11Division of Medicine, University College London, London, London, UK.
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Michael L. Dustin
5Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. United Kingdom.
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Michael Karin
12Laboratory of Gene regulation and Signal Transduction, University California San Diego. USA.
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Alessio Lanna
2Laboratory of NeuroImmuneSenescence, IRCCS Fondazione Santa Lucia, Rome. ITALY
3Sentcell ltd, London, UK.
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  • ORCID record for Alessio Lanna
  • For correspondence: a.lanna@hsantalucia.it
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Article Information

doi 
https://doi.org/10.1101/2020.10.09.331918
History 
  • October 9, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Bruno Vaz2,3,1,
  2. Claudia Vuotto4,1,
  3. Salvatore Valvo5,1,
  4. Clara D’Ambra2,
  5. Francesco Maria Esposito2,
  6. Valerio Chiurchiù6,7,
  7. Oliver Devine8,
  8. Massimo Sanchez9,
  9. Giovanna Borsellino10,
  10. Derek Gilroy11,
  11. Arne N. Akbar8,11,
  12. Michael L. Dustin5,
  13. Michael Karin12 and
  14. Alessio Lanna2,3,*,#
  1. 2Laboratory of NeuroImmuneSenescence, IRCCS Fondazione Santa Lucia, Rome. ITALY
  2. 3Sentcell ltd, London, UK.
  3. 4Experimental Neuroscience, IRCCS Fondazione Santa Lucia, Rome. ITALY
  4. 5Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford. United Kingdom.
  5. 6Institute of Translational Pharmacology, National Research Council, Rome. Italy.
  6. 7Laboratory of resolution of NeuroInflammation, IRCCS Santa Lucia Foundation, Rome, Italy.
  7. 8Division of Infection and Immunity, University College London, London, UK.
  8. 9ISS, Core facilities, Rome. Italy.
  9. 10NeuroImmunology Unit, IRCCS Fondazione Santa Lucia, Rome. ITALY
  10. 11Division of Medicine, University College London, London, London, UK.
  11. 12Laboratory of Gene regulation and Signal Transduction, University California San Diego. USA.
  1. ↵*Corresponding Author: Alessio Lanna Ph.D. a.lanna{at}hsantalucia.it
  1. ↵1 contributed equally

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Posted October 09, 2020.
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Intercellular telomere transfer extends T cell lifespan
Bruno Vaz, Claudia Vuotto, Salvatore Valvo, Clara D’Ambra, Francesco Maria Esposito, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Derek Gilroy, Arne N. Akbar, Michael L. Dustin, Michael Karin, Alessio Lanna
bioRxiv 2020.10.09.331918; doi: https://doi.org/10.1101/2020.10.09.331918
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Intercellular telomere transfer extends T cell lifespan
Bruno Vaz, Claudia Vuotto, Salvatore Valvo, Clara D’Ambra, Francesco Maria Esposito, Valerio Chiurchiù, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Derek Gilroy, Arne N. Akbar, Michael L. Dustin, Michael Karin, Alessio Lanna
bioRxiv 2020.10.09.331918; doi: https://doi.org/10.1101/2020.10.09.331918

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