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CoRa –A general approach for quantifying biological feedback control

View ORCID ProfileMariana Gómez-Schiavon, View ORCID ProfileHana El-Samad
doi: https://doi.org/10.1101/2020.10.09.334078
Mariana Gómez-Schiavon
1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
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  • ORCID record for Mariana Gómez-Schiavon
Hana El-Samad
1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA
2Cell Design Initiative, University of California, San Francisco, CA, USA
3Chan–Zuckerberg Biohub, San Francisco, CA, USA
4Cell Design Institute, San Francisco, CA, USA
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  • For correspondence: hana.el-samad@ucsf.edu
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Abstract

Feedback control is a fundamental underpinning of life, underlying homeostasis of biological processes at every scale of organization, from cells to ecosystems. The ability to evaluate the contribution and limitations of feedback control mechanisms operating in cells is a critical step for understanding and ultimately designing feedback control systems with biological molecules. Here, we introduce CoRa –or Control Ratio–, a general framework that quantifies the contribution of a biological feedback control mechanism to adaptation using a mathematically controlled comparison to an identical system that does not contain the feedback. CoRa provides a simple and intuitive metric with broad applicability to biological feedback systems.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 10, 2020.
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CoRa –A general approach for quantifying biological feedback control
Mariana Gómez-Schiavon, Hana El-Samad
bioRxiv 2020.10.09.334078; doi: https://doi.org/10.1101/2020.10.09.334078
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CoRa –A general approach for quantifying biological feedback control
Mariana Gómez-Schiavon, Hana El-Samad
bioRxiv 2020.10.09.334078; doi: https://doi.org/10.1101/2020.10.09.334078

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