Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

Jessika C. Bridi; Erika Bereczki; Saffron K. Smith; Gonçalo M. Poças; Benjamin Kottler; Pedro M. Domingos; Christopher J. Elliott; Dag Aarsland; Frank Hirth

doi:10.1101/2020.10.12.335778

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Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

View ORCID ProfileJessika C. Bridi, View ORCID ProfileErika Bereczki, View ORCID ProfileSaffron K. Smith, View ORCID ProfileGonçalo M. Poças, View ORCID ProfileBenjamin Kottler, View ORCID ProfilePedro M. Domingos, Christopher J. Elliott, View ORCID ProfileDag Aarsland, View ORCID ProfileFrank Hirth

doi: https://doi.org/10.1101/2020.10.12.335778

Jessika C. Bridi

1King’s College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Department of Basic & Clinical Neuroscience; London, UK

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For correspondence: jessikabridi@usp.br Frank.Hirth@kcl.ac.uk

Erika Bereczki

4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum, Stockholm, Sweden

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Saffron K. Smith

5Department of Biology and York Biomedical Research Institute, University of York, York, YO1 5DD, UK

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Gonçalo M. Poças

3Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Lisbon, Portugal

6School of Biological Sciences, Monash University, Melbourne, Victoria, Australia

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Benjamin Kottler

1King’s College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Department of Basic & Clinical Neuroscience; London, UK

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Pedro M. Domingos

3Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa (ITQB NOVA), Oeiras, Lisbon, Portugal

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Christopher J. Elliott

5Department of Biology and York Biomedical Research Institute, University of York, York, YO1 5DD, UK

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Dag Aarsland

2Department of Old Age Psychiatry, Institute of Psychiatry Psychology and Neuroscience, King’s College London, London, UK

4Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Novum, Stockholm, Sweden

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Frank Hirth

1King’s College London, Institute of Psychiatry, Psychology & Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Department of Basic & Clinical Neuroscience; London, UK

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For correspondence: jessikabridi@usp.br Frank.Hirth@kcl.ac.uk

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Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

Jessika C. Bridi, Erika Bereczki, Saffron K. Smith, Gonçalo M. Poças, Benjamin Kottler, Pedro M. Domingos, Christopher J. Elliott, Dag Aarsland, Frank Hirth

bioRxiv 2020.10.12.335778; doi: https://doi.org/10.1101/2020.10.12.335778

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Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration

Jessika C. Bridi, Erika Bereczki, Saffron K. Smith, Gonçalo M. Poças, Benjamin Kottler, Pedro M. Domingos, Christopher J. Elliott, Dag Aarsland, Frank Hirth

bioRxiv 2020.10.12.335778; doi: https://doi.org/10.1101/2020.10.12.335778

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