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Synapse-specific direction selectivity in retinal bipolar cell axon terminals

View ORCID ProfileAkihiro Matsumoto, Weaam Agbariah, Stella Solveig Nolte, Rawan Andrawos, Hadara Levi, View ORCID ProfileShai Sabbah, View ORCID ProfileKeisuke Yonehara
doi: https://doi.org/10.1101/2020.10.12.335810
Akihiro Matsumoto
1Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 8, 8000 Aarhus C, Denmark
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Weaam Agbariah
2Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
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Stella Solveig Nolte
1Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 8, 8000 Aarhus C, Denmark
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Rawan Andrawos
2Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
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Hadara Levi
2Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
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Shai Sabbah
2Department of Medical Neurobiology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
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  • For correspondence: shai.sabbah@mail.huji.ac.il keisuke.yonehara@dandrite.au.dk
Keisuke Yonehara
1Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Department of Biomedicine, Aarhus University, Ole Worms Allé 8, 8000 Aarhus C, Denmark
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  • For correspondence: shai.sabbah@mail.huji.ac.il keisuke.yonehara@dandrite.au.dk
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Abstract

The ability to encode the direction of image motion is fundamental to our sense of vision. Direction selectivity along the four cardinal directions is thought to originate in direction-selective ganglion cells (DSGCs), due to directionally-tuned GABAergic suppression by starburst cells. Here, by utilizing two-photon glutamate imaging to measure synaptic release, we reveal that direction selectivity along all four directions arises earlier than expected, at bipolar cell outputs. Thus, DSGCs receive directionally-aligned glutamatergic inputs from bipolar cell boutons. We further show that this bouton-specific tuning relies on cholinergic excitation and GABAergic inhibition from starburst cells. In this way, starburst cells are able to refine directional tuning in the excitatory visual pathway by modulating the activity of DSGC dendrites and their axonal inputs using two different neurotransmitters.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted October 12, 2020.
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Synapse-specific direction selectivity in retinal bipolar cell axon terminals
Akihiro Matsumoto, Weaam Agbariah, Stella Solveig Nolte, Rawan Andrawos, Hadara Levi, Shai Sabbah, Keisuke Yonehara
bioRxiv 2020.10.12.335810; doi: https://doi.org/10.1101/2020.10.12.335810
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Synapse-specific direction selectivity in retinal bipolar cell axon terminals
Akihiro Matsumoto, Weaam Agbariah, Stella Solveig Nolte, Rawan Andrawos, Hadara Levi, Shai Sabbah, Keisuke Yonehara
bioRxiv 2020.10.12.335810; doi: https://doi.org/10.1101/2020.10.12.335810

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