Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

Michael X. Henderson; Eli J. Cornblath; Howard L. Li; Lakshmi Changolkar; Bin Zhang; Hannah J. Brown; Ronald J. Gathagan; Modupe F. Olufemi; Danielle S. Bassett; John Q. Trojanowski; Virginia M.Y. Lee

doi:10.1101/2020.10.13.337857

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Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

View ORCID ProfileMichael X. Henderson, Eli J. Cornblath, Howard L. Li, Lakshmi Changolkar, Bin Zhang, Hannah J. Brown, Ronald J. Gathagan, Modupe F. Olufemi, View ORCID ProfileDanielle S. Bassett, John Q. Trojanowski, Virginia M.Y. Lee

doi: https://doi.org/10.1101/2020.10.13.337857

Michael X. Henderson

9Center for Neurodegenerative Science, Van Andel Institute, Grand Rapids, MI 49503

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For correspondence: michael.henderson@vai.org

Eli J. Cornblath

2Department of Bioengineering, School of Engineering & Applied Science

4Department of Neuroscience, Perelman School of Medicine

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Howard L. Li

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Lakshmi Changolkar

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Bin Zhang

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Hannah J. Brown

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Ronald J. Gathagan

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Modupe F. Olufemi

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Danielle S. Bassett

2Department of Bioengineering, School of Engineering & Applied Science

3Department of Electrical & Systems Engineering, School of Engineering & Applied Science

5Department of Physics & Astronomy, College of Arts & Sciences

6Department of Psychiatry, Perelman School of Medicine

7Department of Neurology, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, 19104 USA

8Santa Fe Institute, Santa Fe, NM 87501 USA

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John Q. Trojanowski

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Virginia M.Y. Lee

1Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine

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Tau pathology spreads between anatomically-connected regions of the brain and is modulated by a LRRK2 mutation

Michael X. Henderson, Eli J. Cornblath, Howard L. Li, Lakshmi Changolkar, Bin Zhang, Hannah J. Brown, Ronald J. Gathagan, Modupe F. Olufemi, Danielle S. Bassett, John Q. Trojanowski, Virginia M.Y. Lee

bioRxiv 2020.10.13.337857; doi: https://doi.org/10.1101/2020.10.13.337857

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