Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

Michael Heyne; Jason Shirian; Itay Cohen; Yoav Peleg; Evette S. Radisky; Niv Papo; Julia M. Shifman

doi:10.1101/2020.10.14.338756

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Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

Michael Heyne, Jason Shirian, Itay Cohen, View ORCID ProfileYoav Peleg, View ORCID ProfileEvette S. Radisky, View ORCID ProfileNiv Papo, View ORCID ProfileJulia M. Shifman

doi: https://doi.org/10.1101/2020.10.14.338756

Michael Heyne

1Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

2Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Jason Shirian

1Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

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Itay Cohen

2Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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Yoav Peleg

3Life Sciences Core Facilities (LSCF) Structural Proteomics Unit (SPU), Weizmann Institute of Science, Rehovot, Israel

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Evette S. Radisky

4Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, USA

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Niv Papo

2Avram and Stella Goldstein-Goren Department of Biotechnology Engineering and the National Institute of Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva, Israel

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For correspondence: jshifman@mail.huji.ac.il papo@bgu.ac.il

Julia M. Shifman

1Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

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ORCID record for Julia M. Shifman
For correspondence: jshifman@mail.huji.ac.il papo@bgu.ac.il

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Supplementary Information[supplements/338756_file03.pdf]
Dataset S1 contains all ddGbind values[supplements/338756_file04.xlsx]

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Posted October 14, 2020.

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Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

Michael Heyne, Jason Shirian, Itay Cohen, Yoav Peleg, Evette S. Radisky, Niv Papo, Julia M. Shifman

bioRxiv 2020.10.14.338756; doi: https://doi.org/10.1101/2020.10.14.338756

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Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

Michael Heyne, Jason Shirian, Itay Cohen, Yoav Peleg, Evette S. Radisky, Niv Papo, Julia M. Shifman

bioRxiv 2020.10.14.338756; doi: https://doi.org/10.1101/2020.10.14.338756

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