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A structure-function substrate of memory for spatial configurations in medial and lateral temporal cortices

Shahin Tavakol, Qiongling Li, Jessica Royer, Reinder Vos de Wael, Sara Larivière, Alex Lowe, Casey Paquola, Elizabeth Jefferies, Tom Hartley, Andrea Bernasconi, Neda Bernasconi, Jonathan Smallwood, Veronique Bohbot, Lorenzo Caciagli, Boris Bernhardt
doi: https://doi.org/10.1101/2020.10.14.338947
Shahin Tavakol
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Qiongling Li
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Jessica Royer
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Reinder Vos de Wael
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Sara Larivière
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Alex Lowe
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Casey Paquola
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Elizabeth Jefferies
2University of York, York, UK
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Tom Hartley
2University of York, York, UK
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Andrea Bernasconi
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Neda Bernasconi
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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Jonathan Smallwood
2University of York, York, UK
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Veronique Bohbot
3Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada
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Lorenzo Caciagli
4Department of Bioengineering, University of Pennsylvania, Philadelphia, USA
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Boris Bernhardt
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada
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  • For correspondence: boris.bernhardt@mcgill.ca
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Abstract

Prior research has shown that structures of the mesiotemporal lobe, particularly the hippocampal-parahippocampal complex, are engaged in different forms of spatial cognition. Here, we developed a new paradigm, the Conformational Shift Spatial task (CSST), which examines the ability to encode and retrieve spatial relations between three unrelated items. This task is short, uses symbolic cues, and incorporates two difficulty levels and can be administered inside and outside the scanner. A cohort of 48 healthy young adults underwent the CSST, together with a set of validated behavioral measures and multimodal magnetic resonance imaging (MRI). Interindividual differences in CSST performance correlated with scores on an established spatial memory paradigm, but neither with episodic memory nor pattern separation performance, highlighting the specificity of the new measure. Analyzing high resolution structural MRI data, individuals with better spatial memory showed thicker medial as well as lateral temporal cortices. Functional relevance of these findings was supported by task-based functional MRI analysis in the same participants and ad hoc meta-analysis. Exploratory resting-state functional MRI analyses centered on clusters of morphological effects revealed additional modulation of intrinsic network integration, particularly between lateral and medial temporal structures. Our work presents a novel spatial memory paradigm and supports an integrated structure-function substrate in the human temporal lobe. Task paradigms are programmed in python and made open access.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* joint co-authors

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted October 15, 2020.
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A structure-function substrate of memory for spatial configurations in medial and lateral temporal cortices
Shahin Tavakol, Qiongling Li, Jessica Royer, Reinder Vos de Wael, Sara Larivière, Alex Lowe, Casey Paquola, Elizabeth Jefferies, Tom Hartley, Andrea Bernasconi, Neda Bernasconi, Jonathan Smallwood, Veronique Bohbot, Lorenzo Caciagli, Boris Bernhardt
bioRxiv 2020.10.14.338947; doi: https://doi.org/10.1101/2020.10.14.338947
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A structure-function substrate of memory for spatial configurations in medial and lateral temporal cortices
Shahin Tavakol, Qiongling Li, Jessica Royer, Reinder Vos de Wael, Sara Larivière, Alex Lowe, Casey Paquola, Elizabeth Jefferies, Tom Hartley, Andrea Bernasconi, Neda Bernasconi, Jonathan Smallwood, Veronique Bohbot, Lorenzo Caciagli, Boris Bernhardt
bioRxiv 2020.10.14.338947; doi: https://doi.org/10.1101/2020.10.14.338947

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