Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

The claustrum-medial prefrontal cortex network controls attentional set-shifting

Leon Fodoulian, Olivier Gschwend, Chieko Huber, Sophie Mutel, Rodrigo F. Salazar, Roberta Leone, Jean-Rodolphe Renfer, Kazadi Ekundayo, Ivan Rodriguez, View ORCID ProfileAlan Carleton
doi: https://doi.org/10.1101/2020.10.14.339259
Leon Fodoulian
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olivier Gschwend
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chieko Huber
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sophie Mutel
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rodrigo F. Salazar
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roberta Leone
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jean-Rodolphe Renfer
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazadi Ekundayo
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ivan Rodriguez
2Department of Genetics and Evolution, Faculty of Sciences, quai Ernest-Ansermet, University of Geneva, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: alan.carleton@unige.ch ivan.rodriguez@unige.ch
Alan Carleton
1Department of Basic Neurosciences, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Alan Carleton
  • For correspondence: alan.carleton@unige.ch ivan.rodriguez@unige.ch
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

SUMMARY

In various mental disorders, dysfunction of the prefrontal cortex contributes to cognitive deficits. Here we studied how the claustrum (CLA), a nucleus sharing reciprocal connections with the cortex, may participate in these cognitive impairments. We show that specific ensembles of CLA and of medial prefrontal cortex (mPFC) neurons are activated during a task requiring cognitive control such as attentional set-shifting, i.e. the ability to shift attention towards newly relevant stimulus-reward associations while disengaging from irrelevant ones. CLA neurons exert a direct excitatory input on mPFC pyramidal cells, and chemogenetic inhibition of CLA neurons suppresses the formation of specific mPFC assemblies during attentional set-shifting. Furthermore, impairing the recruitment of specific CLA assemblies through opto/chemogenetic manipulations prevents attentional set-shifting. In conclusion, we propose that the CLA controls the reorganization of mPFC ensembles to enable attentional set-shifting, emphasizing a potential role of the CLA-mPFC network in attentional dysfunctions.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵‡ Lead contact.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
Back to top
PreviousNext
Posted October 15, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
The claustrum-medial prefrontal cortex network controls attentional set-shifting
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
The claustrum-medial prefrontal cortex network controls attentional set-shifting
Leon Fodoulian, Olivier Gschwend, Chieko Huber, Sophie Mutel, Rodrigo F. Salazar, Roberta Leone, Jean-Rodolphe Renfer, Kazadi Ekundayo, Ivan Rodriguez, Alan Carleton
bioRxiv 2020.10.14.339259; doi: https://doi.org/10.1101/2020.10.14.339259
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
The claustrum-medial prefrontal cortex network controls attentional set-shifting
Leon Fodoulian, Olivier Gschwend, Chieko Huber, Sophie Mutel, Rodrigo F. Salazar, Roberta Leone, Jean-Rodolphe Renfer, Kazadi Ekundayo, Ivan Rodriguez, Alan Carleton
bioRxiv 2020.10.14.339259; doi: https://doi.org/10.1101/2020.10.14.339259

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4655)
  • Biochemistry (10307)
  • Bioengineering (7618)
  • Bioinformatics (26203)
  • Biophysics (13453)
  • Cancer Biology (10625)
  • Cell Biology (15348)
  • Clinical Trials (138)
  • Developmental Biology (8456)
  • Ecology (12761)
  • Epidemiology (2067)
  • Evolutionary Biology (16777)
  • Genetics (11361)
  • Genomics (15407)
  • Immunology (10556)
  • Microbiology (25060)
  • Molecular Biology (10162)
  • Neuroscience (54128)
  • Paleontology (398)
  • Pathology (1655)
  • Pharmacology and Toxicology (2877)
  • Physiology (4315)
  • Plant Biology (9204)
  • Scientific Communication and Education (1582)
  • Synthetic Biology (2543)
  • Systems Biology (6753)
  • Zoology (1453)