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Evidence of antigenic imprinting in sequential Sarbecovirus immunization

Huibin Lv, Ray T. Y. So, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Garrick K. Yip, Wilson W. Ng, Ian A. Wilson, Malik Peiris, View ORCID ProfileNicholas C. Wu, Chris K. P. Mok
doi: https://doi.org/10.1101/2020.10.14.339465
Huibin Lv
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Ray T. Y. So
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Meng Yuan
2Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Hejun Liu
2Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Chang-Chun D. Lee
2Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
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Garrick K. Yip
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Wilson W. Ng
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Ian A. Wilson
2Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
3The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, 92037, USA
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Malik Peiris
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Nicholas C. Wu
4Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
5Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA
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  • ORCID record for Nicholas C. Wu
  • For correspondence: nicwu@illinois.edu ch02mkp@hku.hk
Chris K. P. Mok
1HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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  • For correspondence: nicwu@illinois.edu ch02mkp@hku.hk
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SUMMARY

Antigenic imprinting, which describes the bias of antibody response due to previous immune history, can influence vaccine effectiveness and has been reported in different viruses. Give that COVID-19 vaccine development is currently a major focus of the world, there is a lack of understanding of how background immunity influence antibody response to SARS-CoV-2. This study provides evidence for antigenic imprinting in Sarbecovirus, which is the subgenus that SARS-CoV-2 belongs to. Specifically, we sequentially immunized mice with two antigenically distinct Sarbecovirus strains, namely SARS-CoV and SARS-CoV-2. We found that the neutralizing antibodies triggered by the sequentially immunization are dominantly against the one that is used for priming. Given that the impact of the background immunity on COVID-19 is still unclear, our results will provide important insights into the pathogenesis of this disease as well as COVID-19 vaccination strategy.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 15, 2020.
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Evidence of antigenic imprinting in sequential Sarbecovirus immunization
Huibin Lv, Ray T. Y. So, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Garrick K. Yip, Wilson W. Ng, Ian A. Wilson, Malik Peiris, Nicholas C. Wu, Chris K. P. Mok
bioRxiv 2020.10.14.339465; doi: https://doi.org/10.1101/2020.10.14.339465
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Evidence of antigenic imprinting in sequential Sarbecovirus immunization
Huibin Lv, Ray T. Y. So, Meng Yuan, Hejun Liu, Chang-Chun D. Lee, Garrick K. Yip, Wilson W. Ng, Ian A. Wilson, Malik Peiris, Nicholas C. Wu, Chris K. P. Mok
bioRxiv 2020.10.14.339465; doi: https://doi.org/10.1101/2020.10.14.339465

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