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Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs
Frédérik Oger, Cyril Bourouh, Xavier Gromada, Maeva Moreno, Charlène Carney, Emilie Courty, Nabil Rabhi, Emmanuelle Durand, Souhila Amanzougarene, Lionel Berberian, Mehdi Derhourhi, Laure Rolland, Sarah Anissa Hannou, Pierre-Damien Denechaud, Zohra Benfodda, Patrick Meffre, Lluis Fajas, Julie Kerr-Conte, François Pattou, Philippe Froguel, Amélie Bonnefond, View ORCID ProfileJean-Sébastien Annicotte
doi: https://doi.org/10.1101/2020.10.14.339929
Frédérik Oger
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Cyril Bourouh
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Xavier Gromada
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Maeva Moreno
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Charlène Carney
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Emilie Courty
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Nabil Rabhi
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Emmanuelle Durand
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Souhila Amanzougarene
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Lionel Berberian
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Mehdi Derhourhi
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Laure Rolland
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Sarah Anissa Hannou
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Pierre-Damien Denechaud
2Center for Integrative Genomics, Université de Lausanne, CH-1015 Lausanne, Switzerland
Zohra Benfodda
3Univ. Nîmes, EA7352 CHROME, F-30021 Nîmes cedex 1, France
Patrick Meffre
3Univ. Nîmes, EA7352 CHROME, F-30021 Nîmes cedex 1, France
Lluis Fajas
2Center for Integrative Genomics, Université de Lausanne, CH-1015 Lausanne, Switzerland
Julie Kerr-Conte
4Univ. Lille, Inserm, CHU Lille, U1190 - EGID, F-59000 Lille, France
François Pattou
4Univ. Lille, Inserm, CHU Lille, U1190 - EGID, F-59000 Lille, France
Philippe Froguel
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
5Department of Metabolism, Imperial College London, Hammersmith Hospital, London W12 0NN, UK
Amélie Bonnefond
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Jean-Sébastien Annicotte
1Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, CNRS, U1283 - UMR 8199 - EGID, F-59000 Lille, France
Posted October 14, 2020.
Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs
Frédérik Oger, Cyril Bourouh, Xavier Gromada, Maeva Moreno, Charlène Carney, Emilie Courty, Nabil Rabhi, Emmanuelle Durand, Souhila Amanzougarene, Lionel Berberian, Mehdi Derhourhi, Laure Rolland, Sarah Anissa Hannou, Pierre-Damien Denechaud, Zohra Benfodda, Patrick Meffre, Lluis Fajas, Julie Kerr-Conte, François Pattou, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
bioRxiv 2020.10.14.339929; doi: https://doi.org/10.1101/2020.10.14.339929
Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs
Frédérik Oger, Cyril Bourouh, Xavier Gromada, Maeva Moreno, Charlène Carney, Emilie Courty, Nabil Rabhi, Emmanuelle Durand, Souhila Amanzougarene, Lionel Berberian, Mehdi Derhourhi, Laure Rolland, Sarah Anissa Hannou, Pierre-Damien Denechaud, Zohra Benfodda, Patrick Meffre, Lluis Fajas, Julie Kerr-Conte, François Pattou, Philippe Froguel, Amélie Bonnefond, Jean-Sébastien Annicotte
bioRxiv 2020.10.14.339929; doi: https://doi.org/10.1101/2020.10.14.339929
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