Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

Marian Kalocsay; Zoltan Maliga; Ajit J. Nirmal; Robyn J. Eisert; Gary A. Bradshaw; Isaac H Solomon; Yu-An Chen; Roxanne J. Pelletier; Connor A. Jacobson; Julian Mintseris; Robert F. Padera; Amanda J. Martinot; Dan H. Barouch; Sandro Santagata; Peter K. Sorger

doi:10.1101/2020.10.14.339952

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Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

View ORCID ProfileMarian Kalocsay, Zoltan Maliga, Ajit J. Nirmal, Robyn J. Eisert, Gary A. Bradshaw, Isaac H Solomon, Yu-An Chen, Roxanne J. Pelletier, Connor A. Jacobson, Julian Mintseris, Robert F. Padera, Amanda J. Martinot, Dan H. Barouch, Sandro Santagata, Peter K. Sorger

doi: https://doi.org/10.1101/2020.10.14.339952

Marian Kalocsay

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

2Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA

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ORCID record for Marian Kalocsay

Zoltan Maliga

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

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Ajit J. Nirmal

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

3Department of Medical Oncology, Dana Farber Cancer Institute, Boston MA

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Robyn J. Eisert

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

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Gary A. Bradshaw

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

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Isaac H Solomon

4Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

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Yu-An Chen

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

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Roxanne J. Pelletier

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Connor A. Jacobson

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Julian Mintseris

5Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA

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Robert F. Padera

4Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

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Amanda J. Martinot

6Tufts University Cummings School of Veterinary Medicine, North Grafton, MA 01536, USA

7Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

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Dan H. Barouch

7Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

8Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA

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Sandro Santagata

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

4Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA

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Peter K. Sorger

1Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA 02115, USA

2Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA

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For correspondence: peter_sorger@hms.harvard.edu

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Supplementary Table 1[supplements/339952_file02.pdf]
Supplementary Table 2[supplements/339952_file03.xlsx]
Supplementary Table 3[supplements/339952_file04.pdf]
Supplementary Table 4[supplements/339952_file05.xlsx]
Supplementary Table 5[supplements/339952_file06.xlsx]
Supplementary Table 6[supplements/339952_file07.pdf]

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Posted October 15, 2020.

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Multiplexed proteomics and imaging of resolving and lethal SARS-CoV-2 infection in the lung

Marian Kalocsay, Zoltan Maliga, Ajit J. Nirmal, Robyn J. Eisert, Gary A. Bradshaw, Isaac H Solomon, Yu-An Chen, Roxanne J. Pelletier, Connor A. Jacobson, Julian Mintseris, Robert F. Padera, Amanda J. Martinot, Dan H. Barouch, Sandro Santagata, Peter K. Sorger

bioRxiv 2020.10.14.339952; doi: https://doi.org/10.1101/2020.10.14.339952

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