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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, View ORCID ProfileArnaud Millet
doi: https://doi.org/10.1101/2020.10.15.341123
Marie Malier
1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
2Grenoble Alpes University, Grenoble, France
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Magali Court
1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
2Grenoble Alpes University, Grenoble, France
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Khaldoun Gharzeddine
1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
2Grenoble Alpes University, Grenoble, France
3Research department, University Hospital Grenoble-Alpes, Grenoble, France
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Marie-Hélène Laverierre
1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
2Grenoble Alpes University, Grenoble, France
4Department of pathological anatomy and cytology, University Hospital Grenoble-Alpes, Grenoble, France
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Sabrina Marsili
5CRCT Inserm U037, Toulouse University 3, Toulouse, France
6Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France
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Fabienne Thomas
5CRCT Inserm U037, Toulouse University 3, Toulouse, France
6Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France
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Thomas Decaens
2Grenoble Alpes University, Grenoble, France
7Department of Hepatogastroenterology, University Hospital Grenoble-Alpes, Grenoble, France
8Team Tumor Molecular Pathology and Biomarkers, Institute for Advanced Biosciences UMR Inserm 1209 – CNRS 5309, Grenoble, France
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Gael Roth
2Grenoble Alpes University, Grenoble, France
7Department of Hepatogastroenterology, University Hospital Grenoble-Alpes, Grenoble, France
8Team Tumor Molecular Pathology and Biomarkers, Institute for Advanced Biosciences UMR Inserm 1209 – CNRS 5309, Grenoble, France
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Arnaud Millet
1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
2Grenoble Alpes University, Grenoble, France
3Research department, University Hospital Grenoble-Alpes, Grenoble, France
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  • ORCID record for Arnaud Millet
  • For correspondence: arnaud.millet@inserm.fr
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Article Information

doi 
https://doi.org/10.1101/2020.10.15.341123
History 
  • October 15, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Marie Malier1,2,
  2. Magali Court1,2,
  3. Khaldoun Gharzeddine1,2,3,
  4. Marie-Hélène Laverierre1,2,4,
  5. Sabrina Marsili5,6,
  6. Fabienne Thomas5,6,
  7. Thomas Decaens2,7,8,
  8. Gael Roth2,7,8 and
  9. Arnaud Millet1,2,3,#
  1. 1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France
  2. 2Grenoble Alpes University, Grenoble, France
  3. 3Research department, University Hospital Grenoble-Alpes, Grenoble, France
  4. 4Department of pathological anatomy and cytology, University Hospital Grenoble-Alpes, Grenoble, France
  5. 5CRCT Inserm U037, Toulouse University 3, Toulouse, France
  6. 6Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France
  7. 7Department of Hepatogastroenterology, University Hospital Grenoble-Alpes, Grenoble, France
  8. 8Team Tumor Molecular Pathology and Biomarkers, Institute for Advanced Biosciences UMR Inserm 1209 – CNRS 5309, Grenoble, France
  1. ↵#Corresponding author: Arnaud Millet MD PhD, Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences, Batiment Jean Roget 3rd floor, Domaine de la Merci 38700 La Tronche, France, e-mail: arnaud.millet{at}inserm.fr
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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet
bioRxiv 2020.10.15.341123; doi: https://doi.org/10.1101/2020.10.15.341123
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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer
Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet
bioRxiv 2020.10.15.341123; doi: https://doi.org/10.1101/2020.10.15.341123

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