Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier; Magali Court; Khaldoun Gharzeddine; Marie-Hélène Laverierre; Sabrina Marsili; Fabienne Thomas; Thomas Decaens; Gael Roth; Arnaud Millet

doi:10.1101/2020.10.15.341123

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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, View ORCID ProfileArnaud Millet

doi: https://doi.org/10.1101/2020.10.15.341123

Marie Malier

1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France

2Grenoble Alpes University, Grenoble, France

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Magali Court

1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France

2Grenoble Alpes University, Grenoble, France

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Khaldoun Gharzeddine

1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France

2Grenoble Alpes University, Grenoble, France

3Research department, University Hospital Grenoble-Alpes, Grenoble, France

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Marie-Hélène Laverierre

1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France

2Grenoble Alpes University, Grenoble, France

4Department of pathological anatomy and cytology, University Hospital Grenoble-Alpes, Grenoble, France

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Sabrina Marsili

5CRCT Inserm U037, Toulouse University 3, Toulouse, France

6Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France

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Fabienne Thomas

5CRCT Inserm U037, Toulouse University 3, Toulouse, France

6Claudius Regaud Institute, IUCT-Oncopole, Toulouse, France

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Thomas Decaens

2Grenoble Alpes University, Grenoble, France

7Department of Hepatogastroenterology, University Hospital Grenoble-Alpes, Grenoble, France

8Team Tumor Molecular Pathology and Biomarkers, Institute for Advanced Biosciences UMR Inserm 1209 – CNRS 5309, Grenoble, France

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Gael Roth

2Grenoble Alpes University, Grenoble, France

7Department of Hepatogastroenterology, University Hospital Grenoble-Alpes, Grenoble, France

8Team Tumor Molecular Pathology and Biomarkers, Institute for Advanced Biosciences UMR Inserm 1209 – CNRS 5309, Grenoble, France

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Arnaud Millet

1Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences Inserm 1209 – UMR CNRS 5309, Grenoble, France

2Grenoble Alpes University, Grenoble, France

3Research department, University Hospital Grenoble-Alpes, Grenoble, France

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ORCID record for Arnaud Millet
For correspondence: arnaud.millet@inserm.fr

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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet

bioRxiv 2020.10.15.341123; doi: https://doi.org/10.1101/2020.10.15.341123

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Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Marie Malier, Magali Court, Khaldoun Gharzeddine, Marie-Hélène Laverierre, Sabrina Marsili, Fabienne Thomas, Thomas Decaens, Gael Roth, Arnaud Millet

bioRxiv 2020.10.15.341123; doi: https://doi.org/10.1101/2020.10.15.341123

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