Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Spike-timing-dependent plasticity can account for aftereffects of dual-site transcranial alternating current stimulation

View ORCID ProfileBettina C. Schwab, Peter König, Andreas K. Engel
doi: https://doi.org/10.1101/2020.10.16.342105
Bettina C. Schwab
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany
2Institute for Advanced Study Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bettina C. Schwab
  • For correspondence: b.schwab@uke.de
Peter König
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany
3Institute of Cognitive Science, University of Osnabrück, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas K. Engel
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Abstract

Background Transcranial alternating current stimulation (tACS), applied to two brain sites with different phase lags, has been shown to modulate stimulation-outlasting functional connectivity between the targeted regions.

Objective Here, we test if spike-timing-dependent plasticity (STDP) can explain stimulation-outlasting connectivity modulation by dual-site tACS and explore the effects of tACS parameter choices.

Methods Networks with two populations of spiking neurons were simulated. Synapses between the populations were subject to STDP. We re-analyzed resting-state EEG data to validate the model.

Results Simulations showed stimulation-outlasting connectivity changes between in- and anti-phase tACS, dependent on both tACS frequency and conduction delays. Importantly, the model predicted that the largest effects would occur for short conduction delays between the stimulated regions, which agreed with experimental EEG connectivity modulation by 10Hz tACS.

Conclusions STDP can explain connectivity aftereffects of dual-site tACS. However, not all combinations of tACS frequency and application sites are expected to effectively modulate connectivity via STDP. We therefore suggest using appropriate computational models and/or EEG analysis for planning and interpretation of dual-site tACS studies relying on aftereffects.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Back to top
PreviousNext
Posted October 16, 2020.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Spike-timing-dependent plasticity can account for aftereffects of dual-site transcranial alternating current stimulation
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Spike-timing-dependent plasticity can account for aftereffects of dual-site transcranial alternating current stimulation
Bettina C. Schwab, Peter König, Andreas K. Engel
bioRxiv 2020.10.16.342105; doi: https://doi.org/10.1101/2020.10.16.342105
Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Citation Tools
Spike-timing-dependent plasticity can account for aftereffects of dual-site transcranial alternating current stimulation
Bettina C. Schwab, Peter König, Andreas K. Engel
bioRxiv 2020.10.16.342105; doi: https://doi.org/10.1101/2020.10.16.342105

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (2646)
  • Biochemistry (5264)
  • Bioengineering (3678)
  • Bioinformatics (15796)
  • Biophysics (7253)
  • Cancer Biology (5627)
  • Cell Biology (8095)
  • Clinical Trials (138)
  • Developmental Biology (4765)
  • Ecology (7516)
  • Epidemiology (2059)
  • Evolutionary Biology (10576)
  • Genetics (7730)
  • Genomics (10130)
  • Immunology (5192)
  • Microbiology (13904)
  • Molecular Biology (5384)
  • Neuroscience (30779)
  • Paleontology (215)
  • Pathology (878)
  • Pharmacology and Toxicology (1524)
  • Physiology (2254)
  • Plant Biology (5022)
  • Scientific Communication and Education (1041)
  • Synthetic Biology (1385)
  • Systems Biology (4146)
  • Zoology (812)