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Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

Simone Di Sanzo, Katrin Spengler, Anja Leheis, View ORCID ProfileJoanna M. Kirkpatrick, Theresa L. Rändler, View ORCID ProfileTim Baldensperger, View ORCID ProfileLuca Parca, Christian Marx, View ORCID ProfileZhao-Qi Wang, View ORCID ProfileMarcus A. Glomb, View ORCID ProfileAlessandro Ori, Regine Heller
doi: https://doi.org/10.1101/2020.10.16.342311
Simone Di Sanzo
1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
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Katrin Spengler
2Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07743 Jena, Germany
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Anja Leheis
2Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07743 Jena, Germany
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Joanna M. Kirkpatrick
1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
5Proteomics Science Technology Platform, The Francis Crick Institute, MW1 1AT London, UK
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  • ORCID record for Joanna M. Kirkpatrick
Theresa L. Rändler
2Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07743 Jena, Germany
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Tim Baldensperger
3Institute of Chemistry, Food Chemistry, Martin-Luther-University Halle-Wittenberg, 06120, Halle/Saale, Germany
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  • ORCID record for Tim Baldensperger
Luca Parca
4Bioinformatics Unit, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
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  • ORCID record for Luca Parca
Christian Marx
1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
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Zhao-Qi Wang
1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
6Faculty of Biological Sciences, Friedrich-Schiller-University of Jena, Jena, Germany
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Marcus A. Glomb
3Institute of Chemistry, Food Chemistry, Martin-Luther-University Halle-Wittenberg, 06120, Halle/Saale, Germany
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  • ORCID record for Marcus A. Glomb
Alessandro Ori
1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
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  • ORCID record for Alessandro Ori
  • For correspondence: alessandro.ori@leibniz-fli.de regine.heller@med.uni-jena.de
Regine Heller
2Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07743 Jena, Germany
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  • For correspondence: alessandro.ori@leibniz-fli.de regine.heller@med.uni-jena.de
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Article Information

doi 
https://doi.org/10.1101/2020.10.16.342311
History 
  • October 19, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Simone Di Sanzo1,*,
  2. Katrin Spengler2,*,
  3. Anja Leheis2,
  4. Joanna M. Kirkpatrick1,5,
  5. Theresa L. Rändler2,
  6. Tim Baldensperger3,
  7. Luca Parca4,
  8. Christian Marx1,
  9. Zhao-Qi Wang1,6,
  10. Marcus A. Glomb3,
  11. Alessandro Ori1,§,# and
  12. Regine Heller2,§,#,$
  1. 1Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745 Jena, Germany
  2. 2Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, 07743 Jena, Germany
  3. 3Institute of Chemistry, Food Chemistry, Martin-Luther-University Halle-Wittenberg, 06120, Halle/Saale, Germany
  4. 4Bioinformatics Unit, IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy
  5. 5Proteomics Science Technology Platform, The Francis Crick Institute, MW1 1AT London, UK
  6. 6Faculty of Biological Sciences, Friedrich-Schiller-University of Jena, Jena, Germany
  1. ↵#Correspondence should be addressed to: alessandro.ori{at}leibniz-fli.de or regine.heller{at}med.uni-jena.de
  1. ↵* These authors contributed equally to this work.

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Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
bioRxiv 2020.10.16.342311; doi: https://doi.org/10.1101/2020.10.16.342311
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Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
bioRxiv 2020.10.16.342311; doi: https://doi.org/10.1101/2020.10.16.342311

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