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Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules
View ORCID ProfileArik Shams, Sean A. Higgins, View ORCID ProfileChristof Fellmann, View ORCID ProfileThomas J. Laughlin, Benjamin L. Oakes, View ORCID ProfileRachel Lew, Maria Lukarska, Madeline Arnold, Brett T. Staahl, View ORCID ProfileJennifer A. Doudna, View ORCID ProfileDavid F. Savage
doi: https://doi.org/10.1101/2020.10.19.344077
Arik Shams
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Sean A. Higgins
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
2Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
3Scribe Therapeutics, Alameda, CA 94501, USA
Christof Fellmann
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
4Gladstone Institutes, San Francisco, CA 94158, USA
5Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
Thomas J. Laughlin
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
6Division of Biological Sciences, University of San Diego, San Diego, CA 92093, USA
Benjamin L. Oakes
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
2Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
3Scribe Therapeutics, Alameda, CA 94501, USA
Rachel Lew
4Gladstone Institutes, San Francisco, CA 94158, USA
Maria Lukarska
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
2Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Madeline Arnold
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Brett T. Staahl
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
2Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
3Scribe Therapeutics, Alameda, CA 94501, USA
Jennifer A. Doudna
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
2Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA
4Gladstone Institutes, San Francisco, CA 94158, USA
7Graduate Group in Biophysics, University of California, Berkeley, Berkeley, CA 94720, USA
8Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA
9Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA
10Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
11Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA
David F. Savage
1Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Posted October 19, 2020.
Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules
Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas J. Laughlin, Benjamin L. Oakes, Rachel Lew, Maria Lukarska, Madeline Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage
bioRxiv 2020.10.19.344077; doi: https://doi.org/10.1101/2020.10.19.344077
Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules
Arik Shams, Sean A. Higgins, Christof Fellmann, Thomas J. Laughlin, Benjamin L. Oakes, Rachel Lew, Maria Lukarska, Madeline Arnold, Brett T. Staahl, Jennifer A. Doudna, David F. Savage
bioRxiv 2020.10.19.344077; doi: https://doi.org/10.1101/2020.10.19.344077
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