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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity

View ORCID ProfileAdrienne E. D. Stormo, Molly FitzGibbon, Farbod Shavarebi, Elizabeth M. Earley, Lotus S. Lum, Erik Verschueren, Danielle L. Swaney, Gaia Skibinski, Abinaya Ravisankar, Jeffrey van Haren, View ORCID ProfileEmily J. Davis, Jeffrey R. Johnson, John Von Dollen, Christian Mirescu, Ciro Iaccarino, William T. Dauer, R. Jeremy Nichols, Torsten Wittmann, Timothy C. Cox, Steve Finkbeiner, Nevan J. Krogan, Scott A. Oakes, View ORCID ProfileAnnie Hiniker
doi: https://doi.org/10.1101/2020.10.21.336578
Adrienne E. D. Stormo
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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  • ORCID record for Adrienne E. D. Stormo
Molly FitzGibbon
18Department of Pathology, University of California, San Diego, CA, 92093, U.S.A
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Farbod Shavarebi
18Department of Pathology, University of California, San Diego, CA, 92093, U.S.A
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Elizabeth M. Earley
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Lotus S. Lum
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Erik Verschueren
2Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
6Departments of Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Danielle L. Swaney
2Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
6Departments of Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Gaia Skibinski
7Taube/Koret Center for Neurodegenerative Disease Research, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
8Center for Systems and Therapeutics, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
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Abinaya Ravisankar
7Taube/Koret Center for Neurodegenerative Disease Research, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
8Center for Systems and Therapeutics, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
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Jeffrey van Haren
3Departments of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Emily J. Davis
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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  • ORCID record for Emily J. Davis
Jeffrey R. Johnson
2Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
6Departments of Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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John Von Dollen
2Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
6Departments of Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Christian Mirescu
9Neuroscience, Merck & Co. Inc., Boston, MA USA
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Ciro Iaccarino
10Department of Biomedical Sciences, University of Sassari, Sassari, Italy
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William T. Dauer
11Departments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, 75380, U.S.A
12Departments of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, 75380, U.S.A
13Departments of Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, 75380, U.S.A
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R. Jeremy Nichols
14Department of Pathology Stanford University, Palo Alto, CA, 94304, U.S.A
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Torsten Wittmann
3Departments of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
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Timothy C. Cox
15Department of Oral and Craniofacial Sciences, School of Medicine, University of Missouri Kansas City, Kansas City, MO, 64108, U.S.A
16School of Dentistry, and Department of Pediatrics, School of Medicine, University of Missouri Kansas City, Kansas City, MO, 64108, U.S.A
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Steve Finkbeiner
4Departments of Neurology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
5Departments of Physiology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
7Taube/Koret Center for Neurodegenerative Disease Research, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
8Center for Systems and Therapeutics, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
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Nevan J. Krogan
2Departments of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
6Departments of Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA, 94143, U.S.A
8Center for Systems and Therapeutics, J. David Gladstone Institutes, San Francisco, CA, 94158, U.S.A
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Scott A. Oakes
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
17Department of Pathology, University of Chicago, Chicago, IL, 60637, U.S.A
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  • For correspondence: soakes@bsd.uchicago.edu ahiniker@ucsd.edu
Annie Hiniker
1Departments of Pathology, University of California San Francisco, San Francisco, CA, 94143, U.S.A
18Department of Pathology, University of California, San Diego, CA, 92093, U.S.A
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  • ORCID record for Annie Hiniker
  • For correspondence: soakes@bsd.uchicago.edu ahiniker@ucsd.edu
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Posted October 21, 2020.
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Adrienne E. D. Stormo, Molly FitzGibbon, Farbod Shavarebi, Elizabeth M. Earley, Lotus S. Lum, Erik Verschueren, Danielle L. Swaney, Gaia Skibinski, Abinaya Ravisankar, Jeffrey van Haren, Emily J. Davis, Jeffrey R. Johnson, John Von Dollen, Christian Mirescu, Ciro Iaccarino, William T. Dauer, R. Jeremy Nichols, Torsten Wittmann, Timothy C. Cox, Steve Finkbeiner, Nevan J. Krogan, Scott A. Oakes, Annie Hiniker
bioRxiv 2020.10.21.336578; doi: https://doi.org/10.1101/2020.10.21.336578
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity
Adrienne E. D. Stormo, Molly FitzGibbon, Farbod Shavarebi, Elizabeth M. Earley, Lotus S. Lum, Erik Verschueren, Danielle L. Swaney, Gaia Skibinski, Abinaya Ravisankar, Jeffrey van Haren, Emily J. Davis, Jeffrey R. Johnson, John Von Dollen, Christian Mirescu, Ciro Iaccarino, William T. Dauer, R. Jeremy Nichols, Torsten Wittmann, Timothy C. Cox, Steve Finkbeiner, Nevan J. Krogan, Scott A. Oakes, Annie Hiniker
bioRxiv 2020.10.21.336578; doi: https://doi.org/10.1101/2020.10.21.336578

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