RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

Julia Obergasteiger; Anne-Marie Castonguay; Giulia Frapporti; Evy Lobbestael; Veerle Baekelandt; Andrew A. Hicks; Peter P. Pramstaller; Claude Gravel; Corrado Corti; Martin Lévesque; Mattia Volta

doi:10.1101/2020.10.21.348144

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RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

Julia Obergasteiger, Anne-Marie Castonguay, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter P. Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, View ORCID ProfileMattia Volta

doi: https://doi.org/10.1101/2020.10.21.348144

Julia Obergasteiger

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

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Anne-Marie Castonguay

2Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval; CERVO Brain Research Centre, 2601 chemin de la Canardiere, Quebec (QC, Canada)

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Giulia Frapporti

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

◻Department of Cellular, Computational and Integrative Biology-CIBO, University of Trento (Italy)

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Evy Lobbestael

3Department of Neurosciences, KU Leuven, Herestraat 49 bus 1023, 3000, Leuven, Belgium

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Veerle Baekelandt

3Department of Neurosciences, KU Leuven, Herestraat 49 bus 1023, 3000, Leuven, Belgium

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Andrew A. Hicks

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

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Peter P. Pramstaller

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

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Claude Gravel

2Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval; CERVO Brain Research Centre, 2601 chemin de la Canardiere, Quebec (QC, Canada)

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Corrado Corti

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

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Martin Lévesque

2Department of Psychiatry and Neurosciences, Faculty of Medicine, Université Laval; CERVO Brain Research Centre, 2601 chemin de la Canardiere, Quebec (QC, Canada)

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For correspondence: martin.levesque@cervo.ulaval.ca mattia.volta@eurac.edu

Mattia Volta

1Institute for Biomedicine, Eurac Research, via Galvani 31, 39100, Bolzano (Italy)

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ORCID record for Mattia Volta
For correspondence: martin.levesque@cervo.ulaval.ca mattia.volta@eurac.edu

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Posted October 21, 2020.

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RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

Julia Obergasteiger, Anne-Marie Castonguay, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter P. Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, Mattia Volta

bioRxiv 2020.10.21.348144; doi: https://doi.org/10.1101/2020.10.21.348144

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RIT2 reduces LRRK2 kinase activity and protects against alpha-synuclein neuropathology

Julia Obergasteiger, Anne-Marie Castonguay, Giulia Frapporti, Evy Lobbestael, Veerle Baekelandt, Andrew A. Hicks, Peter P. Pramstaller, Claude Gravel, Corrado Corti, Martin Lévesque, Mattia Volta

bioRxiv 2020.10.21.348144; doi: https://doi.org/10.1101/2020.10.21.348144

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