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Mapping the organization and dynamics of the posterior medial network during movie watching

View ORCID ProfileRose A. Cooper, Kyle A. Kurkela, View ORCID ProfileSimon W. Davis, View ORCID ProfileMaureen Ritchey
doi: https://doi.org/10.1101/2020.10.21.348953
Rose A. Cooper
1Department of Psychology and Neuroscience, Boston College
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  • For correspondence: rose.cooper@bc.edu
Kyle A. Kurkela
1Department of Psychology and Neuroscience, Boston College
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Simon W. Davis
2Department of Neurology, Duke University School of Medicine
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Maureen Ritchey
1Department of Psychology and Neuroscience, Boston College
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Abstract

Brain regions within a posterior medial network (PMN) are characterized by sensitivity to episodic tasks, and they also demonstrate strong functional connectivity as part of the default network. Despite its cohesive structure, delineating the intranetwork organization and functional diversity of the PMN is crucial for understanding its contributions to multidimensional event cognition. Here, we probed functional connectivity of the PMN during movie watching to identify its pattern of connections and subnetwork functions in a split-sample replication of 136 participants. Consistent with prior findings of default network fractionation, we identified distinct PMN subsystems: a Ventral PM subsystem (retrosplenial cortex, parahippocampal cortex, posterior angular gyrus) and a Dorsal PM subsystem (medial prefrontal cortex, hippocampus, precuneus, posterior cingulate cortex, anterior angular gyrus). These subsystems were anchored by two complementary regions: Retrosplenial cortex mediated communication between parahippocampal cortex and the Dorsal PM system, and posterior cingulate cortex mediated communication among Dorsal PM regions. Finally, the distinction between PMN subsystems is functionally relevant: whereas both Dorsal and Ventral PM connectivity tracked the movie content, only Ventral PM connections increased in strength at event transitions and appeared sensitive to episodic memory. Overall, these findings provide a model of PMN pathways and reveal distinct functional roles of intranetwork subsystems associated with event cognition.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • http://www.thememolab.org/paper-camcan-pmn/

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted October 22, 2020.
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Mapping the organization and dynamics of the posterior medial network during movie watching
Rose A. Cooper, Kyle A. Kurkela, Simon W. Davis, Maureen Ritchey
bioRxiv 2020.10.21.348953; doi: https://doi.org/10.1101/2020.10.21.348953
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Mapping the organization and dynamics of the posterior medial network during movie watching
Rose A. Cooper, Kyle A. Kurkela, Simon W. Davis, Maureen Ritchey
bioRxiv 2020.10.21.348953; doi: https://doi.org/10.1101/2020.10.21.348953

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