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Unified neural dynamics of decisions and actions in the cerebral cortex and basal ganglia

View ORCID ProfileDavid Thura, Jean-François Cabana, Albert Feghaly, Paul Cisek
doi: https://doi.org/10.1101/2020.10.22.350280
David Thura
Groupe de recherche sur le système nerveux central, Department of Neuroscience, Université de Montréal, Montréal, QC, CANADA
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  • ORCID record for David Thura
Jean-François Cabana
Groupe de recherche sur le système nerveux central, Department of Neuroscience, Université de Montréal, Montréal, QC, CANADA
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Albert Feghaly
Groupe de recherche sur le système nerveux central, Department of Neuroscience, Université de Montréal, Montréal, QC, CANADA
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Paul Cisek
Groupe de recherche sur le système nerveux central, Department of Neuroscience, Université de Montréal, Montréal, QC, CANADA
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  • For correspondence: paul.cisek@umontreal.ca
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Abstract

Several theoretical models suggest that deciding about actions and executing them are not completely distinct neural mechanisms but instead two modes of an integrated dynamical system. Here, we investigate this proposal by examining how neural activity unfolds during a dynamic decision-making task within the high-dimensional space defined by the activity of cells in monkey dorsal premotor (PMd), primary motor (M1), and dorsolateral prefrontal cortex (dlPFC) as well as the external and internal segments of the globus pallidus (GPe, GPi). Dimensionality reduction shows that the four strongest components of neural activity are functionally interpretable, reflecting a state transition between deliberation and commitment, the transformation of sensory evidence into a choice, and the baseline and slope of the rising urgency to decide. Analysis of the contribution of each population to these components shows differences between regions but no distinct clusters within each region. During deliberation, cortical activity unfolds on a two-dimensional “decision manifold” defined by sensory evidence and urgency, and falls off this manifold at the moment of commitment into a choice-dependent trajectory leading to movement initiation. The structure of the manifold varies between regions: In PMd it is curved, in M1 it is nearly perfectly flat, and in dlPFC it is almost entirely confined to the sensory evidence dimension. In contrast, pallidal activity during deliberation is primarily defined by urgency. We suggest that these findings reveal the distinct dynamics of different regions, supporting a unified recurrent attractor model of action selection and execution.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵† CRNL – ImpAct team, Inserm U1028 – University of Lyon 1, 69675 Bron (France) – david.thura{at}inserm.fr

  • ↵‡ Integrated Regional Center of Cancerology (CRIC), Lévis, QC (Canada) - jfcabana{at}outlook.com

  • ↵** Institute for Research in Immunology and Cancer of the University of Montréal, Montréal, QC (Canada) - albert.feghaly{at}umontreal.ca

  • Acknowledgements section updated

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 29, 2020.
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Unified neural dynamics of decisions and actions in the cerebral cortex and basal ganglia
David Thura, Jean-François Cabana, Albert Feghaly, Paul Cisek
bioRxiv 2020.10.22.350280; doi: https://doi.org/10.1101/2020.10.22.350280
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Unified neural dynamics of decisions and actions in the cerebral cortex and basal ganglia
David Thura, Jean-François Cabana, Albert Feghaly, Paul Cisek
bioRxiv 2020.10.22.350280; doi: https://doi.org/10.1101/2020.10.22.350280

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