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In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05

Maiko Ono, Manami Takahashi, Aki Shimozawa, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, Takeharu Minamihisamatsu, Shoko Uchida, Masafumi Shimojo, Yuhei Takado, Hiroyuki Takuwa, Naruhiko Sahara, Ming-Rong Zhang, View ORCID ProfileTakafumi Minamimoto, Masato Hasegawa, Makoto Higuchi
doi: https://doi.org/10.1101/2020.10.23.349860
Maiko Ono
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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  • For correspondence: ono.maiko@qst.go.jp
Manami Takahashi
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Aki Shimozawa
2Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
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Masayuki Fujinaga
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Wakana Mori
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Yuji Nagai
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Koki Mimura
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Takeharu Minamihisamatsu
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Shoko Uchida
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Masafumi Shimojo
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Yuhei Takado
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Hiroyuki Takuwa
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Naruhiko Sahara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Ming-Rong Zhang
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Takafumi Minamimoto
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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  • ORCID record for Takafumi Minamimoto
Masato Hasegawa
2Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
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Makoto Higuchi
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
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Article Information

doi 
https://doi.org/10.1101/2020.10.23.349860
History 
  • October 23, 2020.

Article Versions

  • You are currently viewing Version 1 of this article (October 23, 2020 - 15:14).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Maiko Ono1,3,*,
  2. Manami Takahashi1,3,
  3. Aki Shimozawa2,
  4. Masayuki Fujinaga1,
  5. Wakana Mori1,
  6. Yuji Nagai1,
  7. Koki Mimura1,
  8. Takeharu Minamihisamatsu1,
  9. Shoko Uchida1,
  10. Masafumi Shimojo1,
  11. Yuhei Takado1,
  12. Hiroyuki Takuwa1,
  13. Naruhiko Sahara1,
  14. Ming-Rong Zhang1,
  15. Takafumi Minamimoto1,
  16. Masato Hasegawa2 and
  17. Makoto Higuchi1
  1. 1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
  2. 2Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
  1. ↵* Correspondence: ono.maiko{at}qst.go.jp (M.O.)
  1. ↵3 These authors contributed equally

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Posted October 23, 2020.
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In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
Maiko Ono, Manami Takahashi, Aki Shimozawa, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, Takeharu Minamihisamatsu, Shoko Uchida, Masafumi Shimojo, Yuhei Takado, Hiroyuki Takuwa, Naruhiko Sahara, Ming-Rong Zhang, Takafumi Minamimoto, Masato Hasegawa, Makoto Higuchi
bioRxiv 2020.10.23.349860; doi: https://doi.org/10.1101/2020.10.23.349860
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In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05
Maiko Ono, Manami Takahashi, Aki Shimozawa, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, Takeharu Minamihisamatsu, Shoko Uchida, Masafumi Shimojo, Yuhei Takado, Hiroyuki Takuwa, Naruhiko Sahara, Ming-Rong Zhang, Takafumi Minamimoto, Masato Hasegawa, Makoto Higuchi
bioRxiv 2020.10.23.349860; doi: https://doi.org/10.1101/2020.10.23.349860

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