Article Information
- October 23, 2020.
Author Information
- Maria Teresa Borrello1,8,
- Maria Rita Emma2,8,
- Angela Listi1,
- Marion Rubis1,
- Sergiu Coslet3,
- Giuseppa Augello2,
- Antonella Cusimano2,
- Daniela Cabibi4,
- Rossana Porcasi4,
- Lydia Giannitrapani4,
- Maurizio Soresi4,
- Gianni Pantuso5,
- Karen Blyth6,
- Giuseppe Montalto4,
- Christopher Pin7,
- Melchiorre Cervello2,9 and
- Juan Iovanna1,9
- 1Centre de Recherche en Cancérologie de Marseille, INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France
- 2Consiglio Nazionale Delle Ricerche, Istituto per la Ricerca e l’Innovazione Biomedicale (IRIB), Palermo, Italy
- 3MI-mAbs, Aix-Marseille University, Parc Scientifique et Technologique de Luminy, 13288 Marseille, France
- 4Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy
- 5Department of Surgical Oncological and Oral Sciences, Division of General and Oncological Surgery, University of Palermo, Palermo, Italy
- 6Cancer Research UK Beatson Institute, Glasgow, UK
- 7Children’s Health Research Institute, The University of Western Ontario, London, Ontario, Canada
- ↵9Denotes co-corresponding authors, Corresponding authors address: Juan Iovanna, email: juan.iovanna{at}inserm.fr. Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, 163 Avenue de Luminy, 13288 Marseille, France. Phone: +33-491828803; Mobile Phone: +33-760988158; Fax: +33-491 826083; Melchiorre Cervello, email: melchiorre.cervello{at}irib.cnr.it. Istituto per la Ricerca e l’Innovazione Biomedica (IRIB), Consiglio Nazionale delle Ricerche (CNR), Via Ugo La Malfa n. 153, 90144 Palermo, Italy. Phone: +39-0916809534; Mobile Phone: +39-3336020420; Fax: +39-0916809122
↵8 These authors contributed equally to this work
Authors contribution MTB designed and performed all the mice experiments analyse and interpreted the data-and wrote the manuscript. MRE designed and performed the experiments on patient samples and wrote the manuscript. AL performed the experiments under supervision of MTB.
MR performed the rodent histology and SC helped with histological data interpretation. CA and GA performed in vitro experiments. DC and RP performed IHC analysis. MS gave his support for statistical analysis of human derived data. LG and MG were involved in patient’s enrolment. GP provided surgical resections from morbidly obese patients. KB gave her support in data analysis and critical revision of the manuscript. CP, CM and JI design the study, helped with the data interpretation, supervised MTB and MRE and wrote the manuscript.