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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Zhaolin Yang, Yiliang Wei, Xiaoli S. Wu, Shruti V. Iyer, Moonjung Jung, Emmalee R. Adelman, Olaf Klingbeil, Melissa Kramer, Osama E. Demerdash, Kenneth Chang, Sara Goodwin, Emily Hodges, W. Richard McCombie, Maria E. Figueroa, Agata Smogorzewska, Christopher R. Vakoc
doi: https://doi.org/10.1101/2020.10.23.352070
Zhaolin Yang
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Yiliang Wei
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Xiaoli S. Wu
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
2Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA
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Shruti V. Iyer
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
2Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA
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Moonjung Jung
3Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
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Emmalee R. Adelman
4Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Olaf Klingbeil
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Melissa Kramer
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Osama E. Demerdash
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Kenneth Chang
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Sara Goodwin
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Emily Hodges
5Department of Biochemistry and Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
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W. Richard McCombie
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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Maria E. Figueroa
4Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
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Agata Smogorzewska
3Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
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Christopher R. Vakoc
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
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  • For correspondence: vakoc@cshl.edu
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Article Information

doi 
https://doi.org/10.1101/2020.10.23.352070
History 
  • October 23, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.

Author Information

  1. Zhaolin Yang1,
  2. Yiliang Wei1,
  3. Xiaoli S. Wu1,2,
  4. Shruti V. Iyer1,2,
  5. Moonjung Jung3,
  6. Emmalee R. Adelman4,
  7. Olaf Klingbeil1,
  8. Melissa Kramer1,
  9. Osama E. Demerdash1,
  10. Kenneth Chang1,
  11. Sara Goodwin1,
  12. Emily Hodges5,
  13. W. Richard McCombie1,
  14. Maria E. Figueroa4,
  15. Agata Smogorzewska3 and
  16. Christopher R. Vakoc1,6,*
  1. 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
  2. 2Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA
  3. 3Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA
  4. 4Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
  5. 5Department of Biochemistry and Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
  1. ↵*Correspondence: vakoc{at}cshl.edu
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Posted October 23, 2020.
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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins
Zhaolin Yang, Yiliang Wei, Xiaoli S. Wu, Shruti V. Iyer, Moonjung Jung, Emmalee R. Adelman, Olaf Klingbeil, Melissa Kramer, Osama E. Demerdash, Kenneth Chang, Sara Goodwin, Emily Hodges, W. Richard McCombie, Maria E. Figueroa, Agata Smogorzewska, Christopher R. Vakoc
bioRxiv 2020.10.23.352070; doi: https://doi.org/10.1101/2020.10.23.352070
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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins
Zhaolin Yang, Yiliang Wei, Xiaoli S. Wu, Shruti V. Iyer, Moonjung Jung, Emmalee R. Adelman, Olaf Klingbeil, Melissa Kramer, Osama E. Demerdash, Kenneth Chang, Sara Goodwin, Emily Hodges, W. Richard McCombie, Maria E. Figueroa, Agata Smogorzewska, Christopher R. Vakoc
bioRxiv 2020.10.23.352070; doi: https://doi.org/10.1101/2020.10.23.352070

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