Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Zhaolin Yang; Yiliang Wei; Xiaoli S. Wu; Shruti V. Iyer; Moonjung Jung; Emmalee R. Adelman; Olaf Klingbeil; Melissa Kramer; Osama E. Demerdash; Kenneth Chang; Sara Goodwin; Emily Hodges; W. Richard McCombie; Maria E. Figueroa; Agata Smogorzewska; Christopher R. Vakoc

doi:10.1101/2020.10.23.352070

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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Zhaolin Yang, Yiliang Wei, Xiaoli S. Wu, Shruti V. Iyer, Moonjung Jung, Emmalee R. Adelman, Olaf Klingbeil, Melissa Kramer, Osama E. Demerdash, Kenneth Chang, Sara Goodwin, Emily Hodges, W. Richard McCombie, Maria E. Figueroa, Agata Smogorzewska, Christopher R. Vakoc

doi: https://doi.org/10.1101/2020.10.23.352070

Zhaolin Yang

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Yiliang Wei

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Xiaoli S. Wu

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

2Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA

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Shruti V. Iyer

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

2Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA

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Moonjung Jung

3Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA

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Emmalee R. Adelman

4Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

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Olaf Klingbeil

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Melissa Kramer

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Osama E. Demerdash

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Kenneth Chang

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Sara Goodwin

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Emily Hodges

5Department of Biochemistry and Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

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W. Richard McCombie

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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Maria E. Figueroa

4Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA

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Agata Smogorzewska

3Laboratory of Genome Maintenance, The Rockefeller University, New York 10065, USA

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Christopher R. Vakoc

1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

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For correspondence: vakoc@cshl.edu

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Posted October 23, 2020.

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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

bioRxiv 2020.10.23.352070; doi: https://doi.org/10.1101/2020.10.23.352070

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Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

bioRxiv 2020.10.23.352070; doi: https://doi.org/10.1101/2020.10.23.352070

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