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Tracking cytosine depletion in SARS-CoV-2

View ORCID ProfileRuibang Luo, Yat-Sing Wong, View ORCID ProfileTak-Wah Lam
doi: https://doi.org/10.1101/2020.10.26.354787
Ruibang Luo
Department of Computer Science, The University of Hong Kong, Hong Kong, China
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  • For correspondence: rbluo@cs.hku.hk
Yat-Sing Wong
Department of Computer Science, The University of Hong Kong, Hong Kong, China
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Tak-Wah Lam
Department of Computer Science, The University of Hong Kong, Hong Kong, China
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Abstract

Motivation Danchin et al. have pointed out that cytosine drives the evolution of SARS-CoV-2. A depletion of cytosine might lead to the attenuation of SARS-CoV-2.

Results We built a website to track the composition change of mono-, di-, and tri-nucleotide of SARS-CoV-2 over time. The website downloads new strains available from GISAID and updates its results daily. Our analysis suggests that the composition of cytosine in coronaviruses is related to their reported mortality. Using 137,315 SARS-CoV-2 strains collected in ten months, we observed cytosine depletion at a rate of about one cytosine loss per month from the whole genome.

Availability The website is available at http://www.bio8.cs.hku.hk/sarscov2/.

Contact rbluo{at}cs.hku.hk

Supplementary information Supplementary data are available at Bioinformatics online.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • http://www.bio8.cs.hku.hk/sarscov2/

Copyright 
The copyright holder has placed this preprint in the Public Domain. It is no longer restricted by copyright. Anyone can legally share, reuse, remix, or adapt this material for any purpose without crediting the original authors.
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Posted October 26, 2020.
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Tracking cytosine depletion in SARS-CoV-2
Ruibang Luo, Yat-Sing Wong, Tak-Wah Lam
bioRxiv 2020.10.26.354787; doi: https://doi.org/10.1101/2020.10.26.354787
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Tracking cytosine depletion in SARS-CoV-2
Ruibang Luo, Yat-Sing Wong, Tak-Wah Lam
bioRxiv 2020.10.26.354787; doi: https://doi.org/10.1101/2020.10.26.354787

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