Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

Priyanka Patel; Courtney Buchanan; Amar N. Kar; Seung Joon Lee; Pabitra K. Sahoo; Anatoly Urisman; Juan Oses-Prieto; Michela Dell’Orco; Devon E. Cassidy; Sharmina Miller; Elizabeth Thames; Terika P. Smith; Matthew D. Zdradzinski; Alma L. Burlingame; Nora Perrone-Bizzozero; Jeffery L. Twiss

doi:10.1101/2020.10.26.356162

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Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

Priyanka Patel, View ORCID ProfileCourtney Buchanan, View ORCID ProfileAmar N. Kar, Seung Joon Lee, View ORCID ProfilePabitra K. Sahoo, View ORCID ProfileAnatoly Urisman, Juan Oses-Prieto, Michela Dell’Orco, Devon E. Cassidy, Sharmina Miller, View ORCID ProfileElizabeth Thames, View ORCID ProfileTerika P. Smith, View ORCID ProfileMatthew D. Zdradzinski, View ORCID ProfileAlma L. Burlingame, View ORCID ProfileNora Perrone-Bizzozero, View ORCID ProfileJeffery L. Twiss

doi: https://doi.org/10.1101/2020.10.26.356162

Priyanka Patel

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Courtney Buchanan

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Amar N. Kar

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Seung Joon Lee

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Pabitra K. Sahoo

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Anatoly Urisman

2Department of Pharmaceutical Sciences, University of California, San Francisco, California 94143, USA

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Juan Oses-Prieto

2Department of Pharmaceutical Sciences, University of California, San Francisco, California 94143, USA

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Michela Dell’Orco

3Department of Neurosciences, University of New Mexico School of Health Sciences, Albuquerque, New Mexico 87131, USA

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Devon E. Cassidy

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Sharmina Miller

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Elizabeth Thames

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Terika P. Smith

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Matthew D. Zdradzinski

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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Alma L. Burlingame

2Department of Pharmaceutical Sciences, University of California, San Francisco, California 94143, USA

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Nora Perrone-Bizzozero

3Department of Neurosciences, University of New Mexico School of Health Sciences, Albuquerque, New Mexico 87131, USA

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Jeffery L. Twiss

1Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208, USA

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For correspondence: twiss@mailbox.sc.edu

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Posted October 26, 2020.

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Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs

Priyanka Patel, Courtney Buchanan, Amar N. Kar, Seung Joon Lee, Pabitra K. Sahoo, Anatoly Urisman, Juan Oses-Prieto, Michela Dell’Orco, Devon E. Cassidy, Sharmina Miller, Elizabeth Thames, Terika P. Smith, Matthew D. Zdradzinski, Alma L. Burlingame, Nora Perrone-Bizzozero, Jeffery L. Twiss

bioRxiv 2020.10.26.356162; doi: https://doi.org/10.1101/2020.10.26.356162

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