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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

View ORCID ProfileD. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, View ORCID ProfileC. Griñán-Ferré, View ORCID ProfileM. Pallàs
doi: https://doi.org/10.1101/2020.10.27.356881
D. Puigoriol-Illamola
1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain
2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain
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J. Companys-Alemany
1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain
2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain
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N. Homer
3Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, Edinburgh, United Kingdom
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R. Leiva
4Medicinal Chemistry Section. Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain
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S. Vázquez
4Medicinal Chemistry Section. Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain
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D. Mole
5MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
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C. Griñán-Ferré
1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain
2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain
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  • ORCID record for C. Griñán-Ferré
M. Pallàs
1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain
2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain
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  • ORCID record for M. Pallàs
  • For correspondence: pallas@ub.edu
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Article Information

doi 
https://doi.org/10.1101/2020.10.27.356881
History 
  • October 27, 2020.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. D. Puigoriol-Illamola1,2,
  2. J. Companys-Alemany1,2,
  3. N. Homer3,
  4. R. Leiva4,
  5. S. Vázquez4,
  6. D. Mole5,
  7. C. Griñán-Ferré1,2 and
  8. M. Pallàs1,2,*
  1. 1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain
  2. 2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain
  3. 3Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, Edinburgh, United Kingdom
  4. 4Medicinal Chemistry Section. Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain
  5. 5MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
  1. ↵*Corresponding author: pallas{at}ub.edu
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Posted October 27, 2020.
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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis
D. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, C. Griñán-Ferré, M. Pallàs
bioRxiv 2020.10.27.356881; doi: https://doi.org/10.1101/2020.10.27.356881
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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis
D. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, C. Griñán-Ferré, M. Pallàs
bioRxiv 2020.10.27.356881; doi: https://doi.org/10.1101/2020.10.27.356881

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