RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

D. Puigoriol-Illamola; J. Companys-Alemany; N. Homer; R. Leiva; S. Vázquez; D. Mole; C. Griñán-Ferré; M. Pallàs

doi:10.1101/2020.10.27.356881

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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

View ORCID ProfileD. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, View ORCID ProfileC. Griñán-Ferré, View ORCID ProfileM. Pallàs

doi: https://doi.org/10.1101/2020.10.27.356881

D. Puigoriol-Illamola

1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain

2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain

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ORCID record for D. Puigoriol-Illamola

J. Companys-Alemany

1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain

2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain

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N. Homer

3Mass Spectrometry Core, Edinburgh Clinical Research Facility, Queen’s Medical Research Institute, Edinburgh, United Kingdom

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R. Leiva

4Medicinal Chemistry Section. Department of Pharmacology, Toxicology and Therapeutic Chemistry. Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain

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S. Vázquez

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D. Mole

5MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

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C. Griñán-Ferré

1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain

2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain

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M. Pallàs

1Department of Pharmacology, Toxicology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy and Food Sciences. University of Barcelona, Av Joan XXIII 27-31, 08028 Barcelona, Spain

2Institute of Neuroscience, University of Barcelona (NeuroUB), Passeig de la Vall d’Hebron 171, Barcelona, Spain

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For correspondence: pallas@ub.edu

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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

D. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, C. Griñán-Ferré, M. Pallàs

bioRxiv 2020.10.27.356881; doi: https://doi.org/10.1101/2020.10.27.356881

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RL-118 and 11β-HSD1 target engagement through TAPS assay: behaviour and molecular analysis

D. Puigoriol-Illamola, J. Companys-Alemany, N. Homer, R. Leiva, S. Vázquez, D. Mole, C. Griñán-Ferré, M. Pallàs

bioRxiv 2020.10.27.356881; doi: https://doi.org/10.1101/2020.10.27.356881

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