Abstract
Motivation We propose a system that learns consistent representations of biological entities, such as proteins and diseases, based on a knowledge graph and additional data modalities, like structured annotations and free text describing the entities. In contrast to similar approaches, we explicitly incorporate the consistency of the representations into the learning process. In particular, we use these representations to identify novel proteins associated with diseases; these novel relationships could be used to prioritize protein targets for new drugs.
Results We show that our approach outperforms state-of-the-art link prediction algorithms for predicting unknown protein–disease associations. Detailed analysis demonstrates that our approach is most beneficial when additional data modalities, such as free text, are informative.
Availability Code and data are available at: https://github.com/nle-sztyler/research-doubler
Contact timo.sztyler{at}neclab.eu
Supplementary information Supplementary data are available at Bioinformatics online.
Competing Interest Statement
The authors have declared no competing interest.
