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A novel family of secreted proteins linked to plant gall development

Aishwarya Korgaonkar, Clair Han, Andrew L. Lemire, Igor Siwanowicz, Djawed Bennouna, Rachel Kopec, Peter Andolfatto, Shuji Shigenobu, View ORCID ProfileDavid L. Stern
doi: https://doi.org/10.1101/2020.10.28.359562
Aishwarya Korgaonkar
1Janelia Research Campus of the Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
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Clair Han
1Janelia Research Campus of the Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
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Andrew L. Lemire
1Janelia Research Campus of the Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
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Igor Siwanowicz
1Janelia Research Campus of the Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
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Djawed Bennouna
2Dept. of Human Sciences, Division of Human Nutrition, The Ohio State University, 262G Campbell Hall, 1787 Neil Ave., Columbus, OH 43210
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Rachel Kopec
2Dept. of Human Sciences, Division of Human Nutrition, The Ohio State University, 262G Campbell Hall, 1787 Neil Ave., Columbus, OH 43210
3Ohio State University's Foods for Health Discovery Theme, The Ohio State University, 262G Campbell Hall, 1787 Neil Ave., Columbus, OH 43210
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Peter Andolfatto
4Department of Biology, Columbia University, 600 Fairchild Center, New York, NY 10027, USA
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Shuji Shigenobu
5Laboratory of Evolutionary Genomics, Center for the Development of New Model Organism, National Institute for Basic Biology, Okazaki, 444-8585 Japan
6NIBB Research Core Facilities, National Institute for Basic Biology, Okazaki, 444-8585 Japan
7Department of Basic Biology, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, 444-8585 Japan
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David L. Stern
1Janelia Research Campus of the Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
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  • ORCID record for David L. Stern
  • For correspondence: sternd@janelia.hhmi.org
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Abstract

In an elaborate form of inter-species exploitation, many insects hijack plant development to induce galls—novel plant ‘organs’ resulting from dramatic reprograming of plant cell biology. Insects induce galls by introducing unidentified molecules into plants. Here we identify an aphid gene, determinant of gall color (dgc), that is genetically associated with variation in a gall phenotype, providing the first example of an insect gene implicated in gall development. Dgc encodes a BICYCLE protein, a new family of secreted proteins. Bicycle genes are strongly expressed specifically in galling aphid salivary glands, suggesting they control many aspects of gall development. Bicycle genes have experienced unusually strong diversifying selection, consistent with their potential role controlling gall development in a molecular arms race between aphids and their host plants.

One Sentence Summary Aphid bicycle genes, which encode diverse secreted proteins, contribute to plant gall development.

Competing Interest Statement

HHMI has filed a provisional patent, number 63/092,942, for the inventors AK and DLS covering unique aphid polypeptides for use in modifying plants.

Footnotes

  • https://www.dropbox.com/s/x9ycphtegtis9zy/Video_S1.mp4?dl=0

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted October 28, 2020.
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A novel family of secreted proteins linked to plant gall development
Aishwarya Korgaonkar, Clair Han, Andrew L. Lemire, Igor Siwanowicz, Djawed Bennouna, Rachel Kopec, Peter Andolfatto, Shuji Shigenobu, David L. Stern
bioRxiv 2020.10.28.359562; doi: https://doi.org/10.1101/2020.10.28.359562
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A novel family of secreted proteins linked to plant gall development
Aishwarya Korgaonkar, Clair Han, Andrew L. Lemire, Igor Siwanowicz, Djawed Bennouna, Rachel Kopec, Peter Andolfatto, Shuji Shigenobu, David L. Stern
bioRxiv 2020.10.28.359562; doi: https://doi.org/10.1101/2020.10.28.359562

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