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COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death

Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R. K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
doi: https://doi.org/10.1101/2020.10.29.361048
Rajendra Karki
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Bhesh Raj Sharma
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Shraddha Tuladhar
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Evan Peter Williams
2Department of Microbiology, Immunology, & Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
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Lillian Zalduondo
2Department of Microbiology, Immunology, & Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
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Parimal Samir
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Min Zheng
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Balamurugan Sundaram
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Balaji Banoth
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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R. K. Subbarao Malireddi
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Patrick Schreiner
3The Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Geoffrey Neale
4Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Peter Vogel
5Animal Resources Center and Veterinary Pathology Core, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Richard Webby
6Department of Infectious Disease, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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Colleen Beth Jonsson
2Department of Microbiology, Immunology, & Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
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Thirumala-Devi Kanneganti
1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
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  • For correspondence: Thirumala-Devi.Kanneganti@StJude.org
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Article Information

doi 
https://doi.org/10.1101/2020.10.29.361048
History 
  • October 29, 2020.

Article Versions

  • You are currently viewing Version 1 of this article (October 29, 2020 - 18:26).
  • Version 2 (November 3, 2020 - 09:38).
  • View Version 3, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Rajendra Karki1,*,
  2. Bhesh Raj Sharma1,*,
  3. Shraddha Tuladhar1,
  4. Evan Peter Williams2,
  5. Lillian Zalduondo2,
  6. Parimal Samir1,
  7. Min Zheng1,
  8. Balamurugan Sundaram1,
  9. Balaji Banoth1,
  10. R. K. Subbarao Malireddi1,
  11. Patrick Schreiner3,
  12. Geoffrey Neale4,
  13. Peter Vogel5,
  14. Richard Webby6,
  15. Colleen Beth Jonsson2 and
  16. Thirumala-Devi Kanneganti1,*
  1. 1Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
  2. 2Department of Microbiology, Immunology, & Biochemistry, University of Tennessee Health Science Center, Memphis, TN, 38163, USA
  3. 3The Center for Applied Bioinformatics, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
  4. 4Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
  5. 5Animal Resources Center and Veterinary Pathology Core, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
  6. 6Department of Infectious Disease, St. Jude Children’s Research Hospital, Memphis, TN, 38105, USA
  1. ↵*Correspondence to:, Thirumala-Devi Kanneganti, Department of Immunology, St. Jude Children’s Research Hospital, MS #351, 262 Danny Thomas Place, Memphis TN 38105-3678, Tel: (901) 595-3634; Fax. (901) 595-5766., E-mail: Thirumala-Devi.Kanneganti{at}StJude.org
  1. ↵# Equal Contribution

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COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death
Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R. K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
bioRxiv 2020.10.29.361048; doi: https://doi.org/10.1101/2020.10.29.361048
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COVID-19 cytokines and the hyperactive immune response: Synergism of TNF-α and IFN-γ in triggering inflammation, tissue damage, and death
Rajendra Karki, Bhesh Raj Sharma, Shraddha Tuladhar, Evan Peter Williams, Lillian Zalduondo, Parimal Samir, Min Zheng, Balamurugan Sundaram, Balaji Banoth, R. K. Subbarao Malireddi, Patrick Schreiner, Geoffrey Neale, Peter Vogel, Richard Webby, Colleen Beth Jonsson, Thirumala-Devi Kanneganti
bioRxiv 2020.10.29.361048; doi: https://doi.org/10.1101/2020.10.29.361048

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