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Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro

Bruno Frank, Carina Conzelmann, Tatjana Weil, Rüdiger Groß, Peggy Jungke, Maren Eggers, Janis A. Müller, Jan Münch, Uwe Kessler
doi: https://doi.org/10.1101/2020.10.30.360545
Bruno Frank
1CogniVerde GmbH Groß-Umstadt/Kleinrinderfeld, Germany
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Carina Conzelmann
2Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
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Tatjana Weil
2Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
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Rüdiger Groß
2Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
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Peggy Jungke
3Technische Universität Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
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Maren Eggers
4Labor Prof. Dr. G. Enders MVZ GbR, Stuttgart, Germany
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Janis A. Müller
2Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
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Jan Münch
2Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany
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Uwe Kessler
1CogniVerde GmbH Groß-Umstadt/Kleinrinderfeld, Germany
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  • For correspondence: UK@CogniVerde.de
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Abstract

Many plant juices, extracts and teas have been shown to possess antiviral activity. We here analyzed the virucidal activity of black chokeberry (Aronia melanocarpa), pomegranate (Punica granatum), and elderberry (Sambucus nigra) juice, as well as green tea (Camellia sinensis) against different respiratory viruses. We found that all tested plant derived products effectively inactivated influenza virus, whereas only chokeberry juice diminished SARS-CoV-2 and vaccinia virus infectivity. None of the products inactivated non-enveloped human adenovirus type 5. Thus, black chokeberry juice exerts virucidal activity against different enveloped viral pathogens under in vitro conditions. Whether application of virucidal juices or green tea as oral rinses may lower viral loads in the oral cavity in vivo remains to be evaluated.

Competing Interest Statement

B.F. and U.K. are partners of CogniVerde GmbH Gross-Umstadt, Germany. R.G. acted as a consultant of CogniVerde GmbH, Gross-Umstadt, Germany.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted December 07, 2020.
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Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro
Bruno Frank, Carina Conzelmann, Tatjana Weil, Rüdiger Groß, Peggy Jungke, Maren Eggers, Janis A. Müller, Jan Münch, Uwe Kessler
bioRxiv 2020.10.30.360545; doi: https://doi.org/10.1101/2020.10.30.360545
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Antiviral activity of plant juices and green tea against SARS-CoV-2 and influenza virus in vitro
Bruno Frank, Carina Conzelmann, Tatjana Weil, Rüdiger Groß, Peggy Jungke, Maren Eggers, Janis A. Müller, Jan Münch, Uwe Kessler
bioRxiv 2020.10.30.360545; doi: https://doi.org/10.1101/2020.10.30.360545

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