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The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease

Sandra L. Castro, Emily M. Rocha, Christopher R. Bodle, Katrina E. Johnson, J. Timothy Greenamyre, Briana R. De Miranda
doi: https://doi.org/10.1101/2020.11.02.365775
Sandra L. Castro
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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Emily M. Rocha
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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Christopher R. Bodle
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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Katrina E. Johnson
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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J. Timothy Greenamyre
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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Briana R. De Miranda
1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
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  • For correspondence: BrianaDeMiranda@uabmc.edu
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Article Information

doi 
https://doi.org/10.1101/2020.11.02.365775
History 
  • November 6, 2020.

Article Versions

  • Version 1 (November 3, 2020 - 08:50).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Sandra L. Castro1,
  2. Emily M. Rocha1,
  3. Christopher R. Bodle1,
  4. Katrina E. Johnson1,
  5. J. Timothy Greenamyre1 and
  6. Briana R. De Miranda1,*
  1. 1Pittsburgh Institute for Neurodegenerative Diseases and Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania
  1. ↵*Correspondence should be addressed to Briana R. De Miranda, University of Alabama at Birmingham, 1719 6th Ave South | CIRC 560 | Birmingham, AL 35924, Tel: 205-975-7104, Email: BrianaDeMiranda{at}uabmc.edu
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Posted November 06, 2020.
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The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease
Sandra L. Castro, Emily M. Rocha, Christopher R. Bodle, Katrina E. Johnson, J. Timothy Greenamyre, Briana R. De Miranda
bioRxiv 2020.11.02.365775; doi: https://doi.org/10.1101/2020.11.02.365775
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The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease
Sandra L. Castro, Emily M. Rocha, Christopher R. Bodle, Katrina E. Johnson, J. Timothy Greenamyre, Briana R. De Miranda
bioRxiv 2020.11.02.365775; doi: https://doi.org/10.1101/2020.11.02.365775

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