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Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model
Hiroyuki Takuwa, Asumi Orihara, Yuhei Takado, Takuya Urushihata, Masafumi Shimojo, Ai Ishikawa, Manami Takahashi, Anna M. Barron, Maiko Ono, Jun Maeda, Kazuto Masamoto, Hiroyasu Akatsu, Aviva M. Tolkovsky, Bin Ji, Yutaka Tomita, Hiroshi Ito, Ming-Rong Zhang, Michel Goedert, Maria Grazia Spillantini, Virginia M. -Y. Lee, John Q. Trojanowski, Taketoshi Maehara, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
doi: https://doi.org/10.1101/2020.11.04.368977
Hiroyuki Takuwa
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Asumi Orihara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
2Department of Functional Neurosurgery, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo-ku, Tokyo 113-8519, Japan
Yuhei Takado
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Takuya Urushihata
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Masafumi Shimojo
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Ai Ishikawa
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
3Department of Neurology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan
Manami Takahashi
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Anna M. Barron
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Maiko Ono
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Jun Maeda
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Kazuto Masamoto
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Hiroyasu Akatsu
4Department of Neuropathology, Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan
Aviva M. Tolkovsky
5Department of Clinical Neuroscience, University of Cambridge, Cambridge, CB2 0AH, UK
Bin Ji
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Yutaka Tomita
6Department of Neurology, Keio University School of Medicine, Tokyo 160-0016, Japan
Hiroshi Ito
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Ming-Rong Zhang
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Michel Goedert
7Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK
Maria Grazia Spillantini
5Department of Clinical Neuroscience, University of Cambridge, Cambridge, CB2 0AH, UK
Virginia M. -Y. Lee
8Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-2674, USA
John Q. Trojanowski
8Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-2674, USA
Taketoshi Maehara
2Department of Functional Neurosurgery, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Bunkyo-ku, Tokyo 113-8519, Japan
Tetsuya Suhara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Naruhiko Sahara
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Makoto Higuchi
1National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Article usage
Posted November 05, 2020.
Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model
Hiroyuki Takuwa, Asumi Orihara, Yuhei Takado, Takuya Urushihata, Masafumi Shimojo, Ai Ishikawa, Manami Takahashi, Anna M. Barron, Maiko Ono, Jun Maeda, Kazuto Masamoto, Hiroyasu Akatsu, Aviva M. Tolkovsky, Bin Ji, Yutaka Tomita, Hiroshi Ito, Ming-Rong Zhang, Michel Goedert, Maria Grazia Spillantini, Virginia M. -Y. Lee, John Q. Trojanowski, Taketoshi Maehara, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
bioRxiv 2020.11.04.368977; doi: https://doi.org/10.1101/2020.11.04.368977
Tracking tau fibrillogenesis and consequent primary phagocytosis of neurons mediated by microglia in a living tauopathy model
Hiroyuki Takuwa, Asumi Orihara, Yuhei Takado, Takuya Urushihata, Masafumi Shimojo, Ai Ishikawa, Manami Takahashi, Anna M. Barron, Maiko Ono, Jun Maeda, Kazuto Masamoto, Hiroyasu Akatsu, Aviva M. Tolkovsky, Bin Ji, Yutaka Tomita, Hiroshi Ito, Ming-Rong Zhang, Michel Goedert, Maria Grazia Spillantini, Virginia M. -Y. Lee, John Q. Trojanowski, Taketoshi Maehara, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi
bioRxiv 2020.11.04.368977; doi: https://doi.org/10.1101/2020.11.04.368977
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