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Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress
Jessica Gartrell, Marcia Mellado-Largarde, Nancy E. Martinez, Michael R. Clay, Armita Bahrami, Natasha Sahr, April Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung Plumley, Nathaniel Twarog, Michele Connelly, Koon-Kiu Yan, Jiyang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat
doi: https://doi.org/10.1101/2020.11.05.370155
Jessica Gartrell
1Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Marcia Mellado-Largarde
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Nancy E. Martinez
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Michael R. Clay
3Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado
Armita Bahrami
4Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Natasha Sahr
5Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee
April Sykes
5Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Kaley Blankenship
1Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Lauren Hoffmann
1Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Jia Xie
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Hyekyung Plumley
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Nathaniel Twarog
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Michele Connelly
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Koon-Kiu Yan
6Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Jiyang Yu
6Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Shaina N. Porter
7Department of Cell and Molecular Biology and The Center for Advanced Genomic Engineering, St. Jude Children’s Research Hospital, Memphis, Tennessee
Shondra M. Pruett-Miller
7Department of Cell and Molecular Biology and The Center for Advanced Genomic Engineering, St. Jude Children’s Research Hospital, Memphis, Tennessee
Geoffrey Neale
8Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Christopher L. Tinkle
9Department of Radiation Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Sara M. Federico
1Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Elizabeth A. Stewart
1Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee
10Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee
Anang A. Shelat
2Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee
Article usage
Posted November 05, 2020.
Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress
Jessica Gartrell, Marcia Mellado-Largarde, Nancy E. Martinez, Michael R. Clay, Armita Bahrami, Natasha Sahr, April Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung Plumley, Nathaniel Twarog, Michele Connelly, Koon-Kiu Yan, Jiyang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat
bioRxiv 2020.11.05.370155; doi: https://doi.org/10.1101/2020.11.05.370155
Interrogation of SLFN11 in pediatric sarcomas uncovers an unexpected biological role and a novel therapeutic approach to overcoming resistance to replicative stress
Jessica Gartrell, Marcia Mellado-Largarde, Nancy E. Martinez, Michael R. Clay, Armita Bahrami, Natasha Sahr, April Sykes, Kaley Blankenship, Lauren Hoffmann, Jia Xie, Hyekyung Plumley, Nathaniel Twarog, Michele Connelly, Koon-Kiu Yan, Jiyang Yu, Shaina N. Porter, Shondra M. Pruett-Miller, Geoffrey Neale, Christopher L. Tinkle, Sara M. Federico, Elizabeth A. Stewart, Anang A. Shelat
bioRxiv 2020.11.05.370155; doi: https://doi.org/10.1101/2020.11.05.370155
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