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Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization

View ORCID ProfileZhuoming Liu, Laura A. VanBlargan, View ORCID ProfilePaul W. Rothlauf, Louis-Marie Bloyet, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, View ORCID ProfileElitza S. Theel, View ORCID ProfileAli H. Ellebedy, View ORCID ProfileDaved H. Fremont, View ORCID ProfileMichael S. Diamond, View ORCID ProfileSean P. J. Whelan
doi: https://doi.org/10.1101/2020.11.06.372037
Zhuoming Liu
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
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  • ORCID record for Zhuoming Liu
Laura A. VanBlargan
2Department of Medicine, School of Medicine, Washington University in St. Louis
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Paul W. Rothlauf
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
3Program in Virology, Harvard Medical School, Boston MA
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Louis-Marie Bloyet
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
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Rita E. Chen
2Department of Medicine, School of Medicine, Washington University in St. Louis
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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Spencer Stumpf
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
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Haiyan Zhao
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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John M. Errico
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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Elitza S. Theel
5Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
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  • ORCID record for Elitza S. Theel
Ali H. Ellebedy
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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Daved H. Fremont
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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  • ORCID record for Daved H. Fremont
Michael S. Diamond
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
2Department of Medicine, School of Medicine, Washington University in St. Louis
4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
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  • For correspondence: diamond@wusm.wustl.edu spjwhelan@wustl.edu
Sean P. J. Whelan
1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
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  • For correspondence: diamond@wusm.wustl.edu spjwhelan@wustl.edu
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Article Information

doi 
https://doi.org/10.1101/2020.11.06.372037
History 
  • November 8, 2020.

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  • You are currently viewing Version 1 of this article (November 8, 2020 - 02:38).
  • View Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Zhuoming Liu1,6,
  2. Laura A. VanBlargan2,6,
  3. Paul W. Rothlauf1,3,
  4. Louis-Marie Bloyet1,
  5. Rita E. Chen2,4,
  6. Spencer Stumpf1,
  7. Haiyan Zhao4,
  8. John M. Errico4,
  9. Elitza S. Theel5,
  10. Ali H. Ellebedy1,4,
  11. Daved H. Fremont4,
  12. Michael S. Diamond1,2,4,* and
  13. Sean P. J. Whelan1,7,*
  1. 1Department of Molecular Microbiology, School of Medicine, Washington University in St. Louis
  2. 2Department of Medicine, School of Medicine, Washington University in St. Louis
  3. 3Program in Virology, Harvard Medical School, Boston MA
  4. 4Department of Pathology & Immunology, School of Medicine, Washington University in St. Louis
  5. 5Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
  1. ↵*Correspondence: diamond{at}wusm.wustl.edu (M.S.D), spjwhelan{at}wustl.edu (S. P. J. W.)
  1. ↵6 These authors contributed equally

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Posted November 08, 2020.
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Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Zhuoming Liu, Laura A. VanBlargan, Paul W. Rothlauf, Louis-Marie Bloyet, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, Elitza S. Theel, Ali H. Ellebedy, Daved H. Fremont, Michael S. Diamond, Sean P. J. Whelan
bioRxiv 2020.11.06.372037; doi: https://doi.org/10.1101/2020.11.06.372037
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Landscape analysis of escape variants identifies SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization
Zhuoming Liu, Laura A. VanBlargan, Paul W. Rothlauf, Louis-Marie Bloyet, Rita E. Chen, Spencer Stumpf, Haiyan Zhao, John M. Errico, Elitza S. Theel, Ali H. Ellebedy, Daved H. Fremont, Michael S. Diamond, Sean P. J. Whelan
bioRxiv 2020.11.06.372037; doi: https://doi.org/10.1101/2020.11.06.372037

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