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Widespread Polymodal Chemosensory Receptor Expression in Drosophila Olfactory Neurons

View ORCID ProfileDarya Task, Chun-Chieh Lin, View ORCID ProfileAli Afify, Hongjie Li, Alina Vulpe, View ORCID ProfileKaren Menuz, View ORCID ProfileChristopher J. Potter
doi: https://doi.org/10.1101/2020.11.07.355651
Darya Task
1The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Chun-Chieh Lin
1The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
4Mortimer B. Zuckermann Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
5The Department of Pathology and Laboratory Medicine, Giesel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA
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Ali Afify
1The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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Hongjie Li
2Department of Biology, Stanford University, Stanford, CA 94305, USA
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Alina Vulpe
3Physiology & Neurobiology Department, Institute for Systems Genomics, and Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Mansfield, CT 06269, USA
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Karen Menuz
3Physiology & Neurobiology Department, Institute for Systems Genomics, and Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Mansfield, CT 06269, USA
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Christopher J. Potter
1The Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
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  • For correspondence: cpotter@jhmi.edu
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ABSTRACT

Drosophila olfactory neurons have long been thought to express only one chemosensory receptor modality. Using a new genetic knock-in strategy, we targeted the four co-receptors representing the chemosensory modes in Drosophila (Orco, Ir25a, Ir8a, Ir76b). Co-receptor knock-in expression patterns were verified as accurate representations of endogenous expression. We find extensive overlap in expression among the different co-receptors. As defined by innervation into antennal lobe glomeruli, Ir25a is broadly expressed in 88% of olfactory neuron classes and is co-expressed in 64% of Orco+ neuron classes, including all neuron classes in the maxillary palp. Orco, Ir8a, and Ir76b expression patterns are also expanded. Single sensillum recordings from Orco-expressing Ir25a mutant antennal and palpal neurons identify significant changes in olfactory responses. These results suggest polymodal expression and function of chemosensory receptors is common in olfactory neurons. We present a new map of the olfactory system reflecting this polymodal expression.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted November 08, 2020.
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Widespread Polymodal Chemosensory Receptor Expression in Drosophila Olfactory Neurons
Darya Task, Chun-Chieh Lin, Ali Afify, Hongjie Li, Alina Vulpe, Karen Menuz, Christopher J. Potter
bioRxiv 2020.11.07.355651; doi: https://doi.org/10.1101/2020.11.07.355651
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Widespread Polymodal Chemosensory Receptor Expression in Drosophila Olfactory Neurons
Darya Task, Chun-Chieh Lin, Ali Afify, Hongjie Li, Alina Vulpe, Karen Menuz, Christopher J. Potter
bioRxiv 2020.11.07.355651; doi: https://doi.org/10.1101/2020.11.07.355651

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