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The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb

Inna Schwarz, Monika Müller, Irina Pavlova, Jens Schweihoff, Fabrizio Musacchio, Manuel Mittag, Martin Fuhrmann, Martin K. Schwarz
doi: https://doi.org/10.1101/2020.11.07.372649
Inna Schwarz
1Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty, Venusberg Campus 1, 53105 Bonn
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Monika Müller
2Neuroimmunology & Imaging, Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, Bld.99, 53127 Bonn
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Irina Pavlova
1Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty, Venusberg Campus 1, 53105 Bonn
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Jens Schweihoff
1Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty, Venusberg Campus 1, 53105 Bonn
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Fabrizio Musacchio
2Neuroimmunology & Imaging, Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, Bld.99, 53127 Bonn
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Manuel Mittag
2Neuroimmunology & Imaging, Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, Bld.99, 53127 Bonn
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Martin Fuhrmann
2Neuroimmunology & Imaging, Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Venusberg-Campus 1, Bld.99, 53127 Bonn
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  • For correspondence: Martin.Schwarz@ukbonn.de Martin.Fuhrmann@dzne.de
Martin K. Schwarz
1Institute for Experimental Epileptology and Cognition Research, University of Bonn Medical Faculty, Venusberg Campus 1, 53105 Bonn
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  • For correspondence: Martin.Schwarz@ukbonn.de Martin.Fuhrmann@dzne.de
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Abstract

Sensory perception is modulated in a top-down fashion by higher brain regions to regulate the strength of its own input resulting in the adaptation of behavioral responses. In olfactory perception, the horizontal diagonal band of broca (HDB), embedded in the basal forebrain modulates olfactory information processing by recruiting olfactory bulb (OB) interneurons to shape excitatory OB output. Currently, little is known about how specific HDB to OB top-down signaling affects complex olfactory-mediated behaviors. Here we show that the olfactory bulb is strongly and differentially innervated by HDB projections. HDB-silencing via tetanus toxin light chain led to reduced odor-evoked Ca2+-responses in glomeruli of the OB, underscoring HDB’s role in odor response modulation. Furthermore, selective, light-mediated silencing of HDB to OB afferents completely prevented olfactory-mediated habituation and discrimination behaviors. Notably, also social habituation and discrimination behaviors were affected. Mono-transsynaptic tracing studies indicated a robust HDB innervation from the paraventricular nucleus (PVN). Here we provide evidence for a novel tri-synaptic PVN-HDB-OB axis responsible for modulating these types of behavior. Thus, HDB to OB projections constitute a central top-down pathway for olfactory-mediated habituation and discrimination behaviors.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • We included a novel Figure (Fig. 4, HDB and PVN silenced mice show impaired mounting behavior) in the revised version of the manuscript.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted March 31, 2021.
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The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb
Inna Schwarz, Monika Müller, Irina Pavlova, Jens Schweihoff, Fabrizio Musacchio, Manuel Mittag, Martin Fuhrmann, Martin K. Schwarz
bioRxiv 2020.11.07.372649; doi: https://doi.org/10.1101/2020.11.07.372649
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The diagonal band of broca regulates olfactory-mediated behaviors by modulating odor-evoked responses within the olfactory bulb
Inna Schwarz, Monika Müller, Irina Pavlova, Jens Schweihoff, Fabrizio Musacchio, Manuel Mittag, Martin Fuhrmann, Martin K. Schwarz
bioRxiv 2020.11.07.372649; doi: https://doi.org/10.1101/2020.11.07.372649

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