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Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker II, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, View ORCID ProfileJoseph M. Miano
doi: https://doi.org/10.1101/2020.11.07.372748
Pan Gao
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Qing Lyu
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Amr R. Ghanam
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Cicera R. Lazzarotto
2St. Jude Children’s Research Hospital, Memphis, TN 38195
Gregory A. Newby
3Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA 02142
4Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138
5Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138
Wei Zhang
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Mihyun Choi
6Albany Medical College, Albany, NY 12208
Orazio J. Slivano
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Kevin Holden
7Synthego Corporation, Redwood City, CA 94025
John A. Walker II
7Synthego Corporation, Redwood City, CA 94025
Anastasia P. Kadina
7Synthego Corporation, Redwood City, CA 94025
Rob J. Munroe
8Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853
Christian M. Abratte
8Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853
John C. Schimenti
8Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853
David R. Liu
3Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA 02142
4Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138
5Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138
Shengdar Q. Tsai
2St. Jude Children’s Research Hospital, Memphis, TN 38195
Xiaochun Long
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
6Albany Medical College, Albany, NY 12208
Joseph M. Miano
1Department of Medicine, Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA 30912
Posted November 11, 2020.
Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker II, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, Joseph M. Miano
bioRxiv 2020.11.07.372748; doi: https://doi.org/10.1101/2020.11.07.372748
Prime Editing in Mice Reveals the Essentiality of a Single Base in Driving Tissue-Specific Gene Expression
Pan Gao, Qing Lyu, Amr R. Ghanam, Cicera R. Lazzarotto, Gregory A. Newby, Wei Zhang, Mihyun Choi, Orazio J. Slivano, Kevin Holden, John A. Walker II, Anastasia P. Kadina, Rob J. Munroe, Christian M. Abratte, John C. Schimenti, David R. Liu, Shengdar Q. Tsai, Xiaochun Long, Joseph M. Miano
bioRxiv 2020.11.07.372748; doi: https://doi.org/10.1101/2020.11.07.372748
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