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Differential dopamine receptor-dependent sensitivity improves action selection in the basal ganglia

View ORCID ProfileOlivier Codol, View ORCID ProfilePaul L. Gribble, Kevin N. Gurney
doi: https://doi.org/10.1101/2020.11.12.380451
Olivier Codol
1Department of Psychology, University of Western Ontario, London, ON, Canada
2The University of Sheffield, Sheffield, UK
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  • For correspondence: codol.olivier@gmail.com
Paul L. Gribble
1Department of Psychology, University of Western Ontario, London, ON, Canada
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Kevin N. Gurney
2The University of Sheffield, Sheffield, UK
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Abstract

The problem of selecting one action from a set of different possible actions, simply referred to as the problem of action selection, is a ubiquitous challenge in the animal world. For vertebrates, the basal ganglia (BG) are widely thought to implement the core computation to solve this problem, as the anatomy and physiology of the BG are well-suited to this end. However, the BG still displays physiological features whose role in achieving efficient action selection remains unclear. In particular, it is known that the two types of dopaminergic receptors (D1 and D2) present in the BG give rise to mechanistically different responses. The overall effect will be a difference in sensitivity to dopamine which may have ramifications for action selection. However, which receptor type leads to a stronger response is, a priori, unclear, due to the complexity of the intracellular mechanisms involved. In this study, we use the action selection hypothesis to predict which of D1 or D2 has the greater sensitivity. Thus, we ask - what sensitivity ratio would result in enhanced action selection functionality in the basal ganglia? To do this, we incorporated differential D1 and D2 sensitivity in an existing, high level computational model of the macro-architecture of the basal ganglia, via a simple weighting variable. We then quantitatively assessed the model’s capacity to perform action selection as we parametrically manipulated the new feature. We show that differential (rather than equal) D1 and D2 sensitivity to dopaminergic input improves action selection, and specifically, that greater D1 sensitivity (compared to that for D2) leads to these improvements.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted November 12, 2020.
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Differential dopamine receptor-dependent sensitivity improves action selection in the basal ganglia
Olivier Codol, Paul L. Gribble, Kevin N. Gurney
bioRxiv 2020.11.12.380451; doi: https://doi.org/10.1101/2020.11.12.380451
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Differential dopamine receptor-dependent sensitivity improves action selection in the basal ganglia
Olivier Codol, Paul L. Gribble, Kevin N. Gurney
bioRxiv 2020.11.12.380451; doi: https://doi.org/10.1101/2020.11.12.380451

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