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Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

Evelina Statkute, Anzelika Rubina, Valerie B O’Donnell, David W. Thomas, View ORCID ProfileRichard J. Stanton
doi: https://doi.org/10.1101/2020.11.13.381079
Evelina Statkute
1Systems Immunity University Research Institute, Division of Infection & Immunity, School of Medicine, Heath Park, Cardiff, CF14 4XN
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Anzelika Rubina
1Systems Immunity University Research Institute, Division of Infection & Immunity, School of Medicine, Heath Park, Cardiff, CF14 4XN
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Valerie B O’Donnell
1Systems Immunity University Research Institute, Division of Infection & Immunity, School of Medicine, Heath Park, Cardiff, CF14 4XN
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David W. Thomas
2Advanced Therapies Group, School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY, UK
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  • For correspondence: StantonRJ@cardiff.ac.uk ThomasDW2@cardiff.ac.uk
Richard J. Stanton
1Systems Immunity University Research Institute, Division of Infection & Immunity, School of Medicine, Heath Park, Cardiff, CF14 4XN
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  • ORCID record for Richard J. Stanton
  • For correspondence: StantonRJ@cardiff.ac.uk ThomasDW2@cardiff.ac.uk
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Abstract

The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone had little or no ability to inactivate virus in this assay. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Disclosure: Venture Life Group plc provided information on mouthwash formulations employed in the study, but had no role in funding, planning, execution, analysis or writing of this study. A separate study funded to Cardiff University by Venture Life Group is assessing in vivo efficacy of CPC in patients with COVID19. The investigators declare no direct conflicts exist.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted November 13, 2020.
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Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro
Evelina Statkute, Anzelika Rubina, Valerie B O’Donnell, David W. Thomas, Richard J. Stanton
bioRxiv 2020.11.13.381079; doi: https://doi.org/10.1101/2020.11.13.381079
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Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro
Evelina Statkute, Anzelika Rubina, Valerie B O’Donnell, David W. Thomas, Richard J. Stanton
bioRxiv 2020.11.13.381079; doi: https://doi.org/10.1101/2020.11.13.381079

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