Immune Checkpoint Blockade induces peripheral cytotoxicity and persistence of large effector CD8+ T cell clones

RA Watson; O Tong; R Cooper; CA Taylor; A Verge de Los Aires; EA Mahé; I Nassiri; MR Middleton; BP Fairfax

doi:10.1101/2020.11.15.383786

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Immune Checkpoint Blockade induces peripheral cytotoxicity and persistence of large effector CD8⁺ T cell clones

View ORCID ProfileRA Watson, View ORCID ProfileO Tong, R Cooper, View ORCID ProfileCA Taylor, A Verge de Los Aires, View ORCID ProfileEA Mahé, View ORCID ProfileI Nassiri, MR Middleton, View ORCID ProfileBP Fairfax

doi: https://doi.org/10.1101/2020.11.15.383786

RA Watson

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

3Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, United Kingdom, OX3 7LE

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ORCID record for RA Watson

O Tong

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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ORCID record for O Tong

R Cooper

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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CA Taylor

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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A Verge de Los Aires

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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EA Mahé

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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ORCID record for EA Mahé

I Nassiri

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

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MR Middleton

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

3Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, United Kingdom, OX3 7LE

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BP Fairfax

1MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford, United Kingdom, OX3 9DU

2Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, United Kingdom, OX3 7DQ

3Oxford Cancer and Haematology Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, United Kingdom, OX3 7LE

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ORCID record for BP Fairfax
For correspondence: benjamin.fairfax@oncology.ox.ac.uk

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Immune Checkpoint Blockade induces peripheral cytotoxicity and persistence of large effector CD8⁺ T cell clones

RA Watson, O Tong, R Cooper, CA Taylor, A Verge de Los Aires, EA Mahé, I Nassiri, MR Middleton, BP Fairfax

bioRxiv 2020.11.15.383786; doi: https://doi.org/10.1101/2020.11.15.383786

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Immune Checkpoint Blockade induces peripheral cytotoxicity and persistence of large effector CD8⁺ T cell clones

RA Watson, O Tong, R Cooper, CA Taylor, A Verge de Los Aires, EA Mahé, I Nassiri, MR Middleton, BP Fairfax

bioRxiv 2020.11.15.383786; doi: https://doi.org/10.1101/2020.11.15.383786

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